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1、抑癌基因PTEN在子宫内膜癌组织中的表达【关键词】子宫内膜癌ExpressionoftumorsuppressorgenePTENinendometrialcarcinomaMAJiaJia,CHENBiLiang,MAXiangDong,WANGDeTang,GUOHuiLingDepartmentofGynecologyandObstetrics,XijingHospital,FourthMilitaryMedicalUniversity,Xi’an710033,China【Abstract】AIM:To
2、investigatetheeffectsoftumorsuppressorgenePTENinthecarcinogenesisanddevelopmentoftheendometrialcarcinomaandtoidentifythecorrelationsbetweentheexpressionofPTENandtheclinicopathologicfactorsofendometrialcarcinoma.METHODS:Seventysevenendometrialcarcinomasample
3、swereimmunohitochemicallyanalyzed,72ofwhichwereadenoendometrialcarcinomaand25normalendometriumsamplesforPTENexpression.Resultswerecomparedwiththeclinicopathologicfactors,suchastype,stage,grade,myometrialinvasion,lymphinvasionandage.RESULTS:LossofPTENprotein
4、expressioninendometrialcarcinoma(60%)wasmuchmorefrequentthanthoseofnormalendometriumtissues(0%,P=0.0000)andtheexpressionlevelofPTENvariedbetweenthetwodifferenthistologicaltypes(64%vs0%,P=0.0048)andthepathologicalgrade.LossofPTENproteinexpressionincreasedwit
5、hthemalignancygradeofendometrialcarcinoma(P=0.0034)butwasnotassociatedwithclinicalstages,myometrialinvasion,lymphinvasionandages.CONCLUSION:TumorsuppressorgenePTENplaysanimportantroleinthecarcimogenesisanddevelopmentoftheendometrialcarcinoma.ThelossofPTENex
6、pressioniscloselyrelatedtothecarcinogenesisanddevelopmentoftheendometrialcarcinoma,especiallytheadenoendometrialtumorigenesis.【Keywords】PTEN;tumorsuppressorgene;endometrialcarcinoma;geneexpression;immunohistochemistry【摘要】目的：了解抑癌基因PTEN在子宫内膜癌中的表达及与子宫内膜癌临床病理因素
7、的相关性，探讨其与子宫内膜癌发生发展的关系.方法：运用免疫组织化学SABC法测定PTEN蛋白在77（子宫内膜样腺癌72，子宫浆液性癌5）例子宫内膜癌组织和25例正常子宫内膜中的表达，并比较PTEN表达变化与组织学类型、手术临床分期、病理分级、子宫肌层浸润程度、淋巴结转移及患者年龄等临床病理因素之间的相关性.结果：子宫内膜癌组织中PTEN表达缺失率为60%，与正常子宫内膜相比（0%）存在显著性差异（P=0.0000）.子宫内膜样腺癌中PTEN的失表达率为64%，而子宫浆液性癌为0%，二者差异显著（P=0.004
8、8）.PTEN的失表达率随内膜癌恶性程度的增加而增加（P=0.0034），但与手术临床分期、肌层浸润程度、淋巴结转移及患者年龄等因素无关（P＞0.05）.结论：抑癌基因PTEN是在子宫内膜癌发生过程中占重要地位的突变基因，PTEN基因的失表达与子宫内膜癌，特别是子宫内膜样腺癌的发生发展密切相关.【关键词】PTEN;抑癌基因;子宫内膜癌;基因表达;免疫组织化学0引言子宫内膜癌是女性生殖系统常见的恶性肿
