促排卵卵泡大小与妊娠率及妊娠结局的关系

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1、促排卵卵泡大小与妊娠率及妊娠结局的关系【摘要】目的通过超声观察药物诱发排卵卵泡发育情况、卵泡大小与妊娠率、妊娠结局的关系,旨在探索促排卵正常成熟卵泡大小范围值及最易妊娠卵泡径线范围值。方法2005.032006.09广东医学院附属医院和湛江市霞山妇幼保健院对因排卵功能障碍所致不孕妇女190例进行药物诱发排卵治疗共476个促排卵周期,采用超声监测排卵，并按卵泡大小分组对照观察其周期妊娠率及妊娠结局。结果促排卵正常成熟卵泡直径范围为20～30mm，平均直径（25.12±3.26）mm;正常排卵周期共373个，周期排卵率78.36%；妊娠172例,周期妊娠率46.11%；卵泡直径24～

2、28mm组、20～23mm组、29～30mm组的周期妊娠率分别为65.52%、23.28%、20.37%，自然流产率分别为6.02%、40.74%、45.45%，周期妊娠率前组显著高于后两组（P<0.01）；周期自然流产率前组显著低于后两组（P<0.01)。结论超声对促排卵正常成熟卵泡大小范围值及最易妊娠卵泡径线范围值的探索与研究，将有利于指导临床医生及时调整治疗方案及用药剂量，提高促排卵周期妊娠率及妊娠成功率，减少和预防并发症的发生。【关键词】促排卵；成熟卵泡；周期妊娠率；妊娠结局；超声监测基金项目：湛江市科技攻关立项项目(湛科［2005］919)Therelationship

3、betweenovarianfolliclesizeinducedbydrugovulationfacilitationandpregnantrateandpregnantoutcomeFANYuhua,LUOGuixian,WUFei,WENQingxia,,LUOZhiming(MaternalandChildHealthHospitalofXiashanDistrict,ZhanjiangCity,Zhanjiang524013,China)Abstract：ObjectiveTostudytherelationshipbetweenovarianfolliclesi

4、zeinducedbydrugovulationfacilitationandpregnantrateandpregnantoutcome,andtofindthecommonandeasypregnantfolliclesizevalueintheovarytreatedwithdrugovulationfacilitation.Methods476ovulationfacilitationcyclesfrom190womentreatedwithdrugovulationfacilitationbecauseofmalovulationinTheAffiliatedHosp

5、italofGuangdongMedicalCollegeandMaternalandChildHealthHospitalinXiashanDistrict(ZhjiangCity)fromMarch2005toSeptember2006wereobservedwithultrasound.Thefolliclesizewasdeterminedanddividedintogroups,amongwhichthepregnantrateandpregnantoutcomewerecompared.ResultsThecommonfolliculardiameterswere20～

6、30mm,withtheaverage(25.12±3.26)mm;373outof476ovulationfacilitationcyclesbelongedtothenormalovulationcycles,withanovulationrateof75.36%andapregnantrateof46.11%in172pregnantwomen.Ingroupswithfolliculardiameter24～28mm,20～23mmand29～30mm,thecyclepregnantrateswere65.52%,23.28%and20.37%,andthespontan

7、eousabortionrateswere6.02%,40.74%and45.45%,respectively.The24～28mmgrouphadahighercyclepregnancyrateandlowerspontaneousabortionratethandidthe20～23mmand29～30mmgroups（P＜0.01）.ConclusionThecommonfolliculardiametersinducedwithdrugovulationfa