scale up optimization using simulation experiments the visimix利用模拟实验的规模visimix优化.ppt

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1、ScaleupoptimizationusingsimulationexperimentsM.Bentolila,R.S.Kenett,S.Malca,R.Novoa,M.Hasson,B.N.YoskovichPerrigoILStructurePerrigoILPharmaInt’l.ConsumerProdFinanceInfo.SystemsLogisticsBusinessDevelopmentHumanResourcesDanAgisAgisInvestNecaCarelineNaturalFormulaPerrigoIsraelPharmaceuticalsLtd.ChemA

2、gisLtd.ChemAgisIsraelChemAgisUSAChemAgisGermany(GmbH)ZiboXinhua-PerrigoPharmaJVPharmaILPerrigoNYnamesIntellectualCapitalChemAgisIsrael6Days*3shiftsR&DOrganizationChartChemagis’personnelconstantlystrivetodevelopnewtechnologiesandprocessesthatmeetthestringentscientificandregulatorydemandsandchallen

3、gestosupporttoday'sglobalmarkets.OurProductsGenericAPI–ActivePharmaceuticalIngredientsproduction:30productspyExamplesofrourproducts:PentoxifyllineVasodilatorPramipexoleDihydrochlorideAntiParkinsonianRocuroniumBromideNeuromuscularblockerTemozolomideAntineoplastic,alkylatingagentTerbinafineHydrochl

4、orideAntidermatophyte(fungalinfectionsofthenails)TramadolHydrochlorideAnalgesicZonisamideAntiepilepticScaleUpMethodology(J.M.Berty.CEP,1979)ScaleUpMethodology(J.M.Berty.CEP,1979)Before20012001-20052005-AdvancedpoorcombinedBefore2001Thescale-upprocesscolumnardidn’tuseanysimulationtools2001-2005Visi

5、mixandDynochemDOE–DesignOfExperiments2005-VisimixDynochemVisiMix–Mixingsimulationandcalculationsoftware.Mathematicalmodelingofmixingphenomena.Calculationofaverageandlocalcharacteristicsofmixingflowanddistributionofconcentration.Simulationandcalculationofreal“nonperfect”mixing.DynoChem–Chemicaldyna

6、micsimulationsoftware.Fittingifchemicalreactionmodels.Predictionofscale-upconditions.Optimizationoflaboratoryandproductionresults.Equipmentcharacterization.Showseffectsofscaledependentphysicalphenomena(mixing,heattransfer,masstransfer).Dynochemcanbeusedforsimulationofreactionsperformedinhomogenous

7、environment.WhenmixingisnotidealandthesolutionisnothomogenousVisiMixisusedforfindingtherequiredmixingconditions.TheprogramsusedforModelingsimulationandoptimization:TImeTomarketreductionviaStatisticalInformationMa