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时间:2020-04-08
《急性脑梗死患者血清标志物p-选择素的动态测定及临床研究.doc》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、急性脑梗死患者血清标志物P-选择素的动态测定及临床研究【摘要】冃的动态观察急性脑樓死(ACI)患者血清P-选择素(P-selectin)的表达特点。并探讨它们与神经功能缺损程度及年龄性别等方面的相关性。方法应用酶联免疫法(ELTSA)动态观察52例ACT患者血清P-select.in的变化,并与52例健康对照者对比,同时应用NIHSS进行神经功能缺损评分。结果血清P-selectin在ACT发病后早期显著高于正常对照组(P0.05)o血清P-selectin水平与临床神经功能缺损程度评分无相关性。结论ACI早期存在血小板活化、它参与了脑组
2、织的缺血性损伤,形成脑梗死早期的发病基础,并参与急性脑梗死的病理生理过程。P-selectin虽然参与发病,但不能预测ACI的致残性和近期预后。【关键词】急性脑樓死;P-选择素;神经功能缺损评分Correiativestudyandseriallyassayof卩-selectininpatientswithacutecerebralinfarctionCHANGHui-jun,ZHANGQi-xiang,LUHong,etal.TheCentralHospitalofXinxiangCity;DepartmentofNeurology,
3、theSecondAffi1iatedHospitalofXiuxaingMedicalCollege,Henan45300,China[Abstract]ObjectiveTostudytheserialchangesoftheexpressionof卩一seiectinconcentrationsinserumfrompatientswithacutecerebralinfarction(ACI)andtofindthecorrelationswithneurologicaldeficitsofACI,sexandageetc.Met
4、hodsTheP-selectinconcentrationswereseriallydeterminedinthe52inpatientswithACIand52controlsubjects.Assayswereperformedbyusingenzyme1inkedimmunosorbentassay(ELTSA).Atthesametimetheneurologicaldeficitsstateswereevaluatedbythenationalinstiluteofhealthstrokescale(NIIISS)•Resul
5、tsThelevelsofserumP-selectininpatientswithACIwithin15daysaftertheonsetweresignificantlyhigherthanthatinnormalcontrols(P0.05).ThereleasesofP-selectininpatientsafterischemicstrokewerenotassociatedwiththeneurologicaloutcomeasassessedbyNIHSS・PeakedconcentrationsofP-selectinwe
6、renotassociatedwiththesexandageetc.ConclusionPlateletactivationswereobservedinpatientswithACI.Itwasinvolvedincerebralischemicinjury.ItcouldbethebasisofearlyACTpathogenesisandparticipatesinthedifferentialpathogenesisprocessofACI.AlthoughP-selectinparticipatedinthepathogene
7、sis,itcouldnotpredictthedisabilityofACTanditsprognosisinthenearfuture.[Keywords]Acutecerebralinfarction;P-selectin;NIIISS作者单位:45300新乡市屮心医院(畅慧君张其相赵建民);新乡医学院第二附属医院神经内科(卢红)急性脑梗死是一种常见口致残率、致死率很高的疾病,而口.其致残率也是最高的,远远高于致死率[1],给国家、社会和家庭带来了巨大的经济与精神负担。影响脑卒屮发病及其预后的因素多而复朵,且脑梗死一旦发病,只有超早
8、期做出诊断,积极抢救缺血半暗带,才会提高疗效,改善预后。因此,寻找脑樓死新的致病致残危险因素以及有助于早期诊断的指标,以便为临床开展新的预防及治疗措施奠定理论皋础。通常在脑梗死形成中最早发生的
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