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1、急性脑梗死患者血清标志物P-选择素动态测定及临床探究【摘要】目的动态观察急性脑梗死(ACI)患者血清P-选择素(P-selectin)的表达特点。并探讨它们与神经功能缺损程度及年龄性别等方面的相关性。方法应用酶联免疫法(ELISA)动态观察52例ACI患者血清P-selectin的变化,并与52例健康对照者对比,同时应用NIHSS进行神经功能缺损评分。结果血清P-selectin在ACI发病后早期显著高于正常对照组(P0.05)。血清P-selectin水平与临床神经功能缺损程度评分无相关性。结论A
2、CI早期存在血小板活化、它参与了脑组织的缺血性损伤,形成脑梗死早期的发病基础,并参与急性脑梗死的病理生理过程。P-selectin虽然参与发病,但不能预测ACI的致残性和近期预后。【关键词】急性脑梗死;P-选择素;神经功能缺损评分CorrelativestudyandseriallyassayofP-selectininpatientswithacutecerebralinfarctionCHANGHui-jun,ZHANGQi-xiang,LUHong,etal.TheCentralHospita
3、lofXinxiangCity;DepartmentofNeurology,theSecondAffiliatedHospitalofXiuxaingMedicalCollege,Henan1045300,China【Abstract】ObjectiveTostudytheserialchangesoftheexpressionofP-selectinconcentrationsinserumfrompatientswithacutecerebralinfarction(ACI)andtofindt
4、hecorrelationswithneurologicaldeficitsofACI,sexandageetc.MethodsTheP-selectinconcentrationswereseriallydeterminedinthe52inpatientswithACIand52controlsubjects.Assayswereperformedbyusingenzymelinkedimmunosorbentassay(ELISA).Atthesametimetheneurologicalde
5、ficitsstateswereevaluatedbythenationalinstituteofhealthstrokescale(NIHSS).ResultsThelevelsofserumP-selectininpatientswithACIwithin15daysaftertheonsetweresignificantlyhigherthanthatinnormalcontrols(P0.05).ThereleasesofP-selectininpatientsafterischemicst
6、rokewerenotassociatedwiththeneurologicaloutcomeasassessedbyNIHSS.PeakedconcentrationsofP-selectinwerenotassociatedwiththesexandageetc.ConclusionPlateletactivationswereobservedinpatientswithACI.Itwasinvolvedincerebral10ischemicinjury.Itcouldbethebasisof
7、earlyACIpathogenesisandparticipatesinthedifferentialpathogenesisprocessofACI.AlthoughP-selectinparticipatedinthepathogenesis,itcouldnotpredictthedisabilityofACIanditsprognosisinthenearfuture.【Keywords】Acutecerebralinfarction;P-selectin;NIHSS作者单位:45300新
8、乡市中心医院(畅慧君张其相赵建民);新乡医学院第二附属医院神经内科(卢红)急性脑梗死是一种常见且致残率、致死率很高的疾病,而且其致残率也是最高的,远远高于致死率[1],给国家、社会和家庭带来了巨大的经济与精神负担。影响脑卒中发病及其预后的因素多而复杂,且脑梗死一旦发病,只有超早期做出诊断,积极抢救缺血半暗带,才会提高疗效,改善预后。因此,寻找脑梗死新的致病致残危险因素以及有助于早期诊断的指标,以便为临床开展新的预防及治疗措施奠定理论基础。通常在脑梗死形成中最早发生的是
