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时间:2020-04-12
《单侧突发性聋慢性期及急性期患者的静息态功能磁共振成像研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、现代中西医结合杂志ModernJournalofIntegratedTraditionalChineseandWesternMedicine2015Mar,24(9)921·单侧突发性聋慢性期及急性期患者的静息态功能磁共振成像研究王伟,黄志纯,杨明,刘斌,朱新,冯源,卢春强(1.东南大学医学院,江苏南京210009;2东南大学附属中大医院,江苏南京210009)[摘要]目的采用低频振幅(ALFF)的方法比较单侧突发性聋慢性期及急性期患者静息态功能磁共振成像(fMRI)的差异。方法选取左侧突发性聋2年后的慢性期患者
2、18例(慢性期组)及左侧突发性聋急性期患者18例(急性期组),分别行静息态fMRI数据采集,用ALFF方法比较2组ALFF值改变的脑区。结果静息状态下,慢性期组右侧岛叶、右侧额下回脑区ALFF值较急性期纽增高(P均<0.05),右侧颞中回、左侧颞下回、双侧内侧前额叶、右侧小脑脑区ALFF值较急性期组降低(P均<0.05)。结论单侧突发性聋慢性期患者较单侧突发性聋急性期患者存在静息态下脑功能区自发活动异常。[关键词]突发性聋;静息态fMRI;低频振幅doi:10.3969/j.issn.1008—8849.2015
3、.09.003[中图分类号】R0764.437[文献标识码]A[文章编号]1008—8849(2015)09—0921一O3StudyofrestingstatefMRIonpatientswithsuddendeafnessinchronicandacutestageWANGWei,HUANGZhichun,YANGMing,LIUBin,ZHUXin,FENGYuan,LUChunqiang。(1.MedicineCollegeofSoutheastUniversity,Nanjing210009,Jiang
4、su,China;2.ZhongdaHospitalofSoutheastUniversity,Nanjing210009,Jiangsu,China)Abstract:ObjectiveItistocomparethedifferencesoftherestingstatefMRIbetweentheacuteandchronicphaseofsuddendeafnessbylowfrequencyamplitude(ALFF).Methods18caseswithsuddendeafnessoftheleft
5、sideinchronicphaseafterdeafnessfortwoyearswereselectedintochronicphasegroup,and18casesinacutephasewereselectedintoacutephasegroup.ThedataacquisitionofrestingstatefMRIinbothgroupswasperformed,respectively.Theareasofthebrainwithchangesoflowfrequencyamplitude(AL
6、FF)valueintwogroupswerecompared.ResultsOntherestingstate,theALFFval,ueoftherightinsula,rightsuperiortemporalgyrusregionsinchronicphasegroupwereincreasedmarkedlythanthatinacutephasegroup(allP<0.05),andtheALFFvalueoftherightmiddletemporalgyrus,leftinferiortempo
7、ralgyrus,bilateralme—dialfrontalgyrus,rightcerebellumregionsinchronicphasegroupweremarkedlyreducedthanthatinacutephasegroup(allP<0.05.ConclusionPatientswithsuddendeafnessinchronicphaseexistscerebralfunctionabnormalofspontaneousactiv—ityundertherestingstatecom
8、paretoacutephasegroup.Keywords:suddendeafness;reststatefunctionalMagneticResonanceImaging;lowfrequencyamplitude突发性聋为突然发生的原因不明的感音神经性听力损性聋慢性期与急性期患者静息态下局部脑区ALFF值的差失,多表现为在3d内听力急剧下降,本病为耳鼻咽喉科的一
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