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1、·72·中国疼痛医学杂志ChineseJournalofPainMedicine2009,15,(2)联合黛力新治疗伴有情感障碍慢性紧张型头痛随机对照研究刘光健王云甫刘勇罗国君何国厚(郧阳医学院附属太和医院神经内科,湖北十堰442000)摘要目的:评价联合黛力新治疗伴有情感障碍慢性紧张型头痛(CTH)的效果。方法:将60例患者随机分为A组(氨酚氯宗分散片和硫必利),B组(氨酚氯宗分散片、硫必利和黛力新),疗程6周;于治疗前及治疗后2、4、6周末,记录患者头痛程度(HD)、周发作频次(WPF)、每次发作持续时间(STP)和焦虑指数(HAMA)、抑郁指数(HAMD)。结果
2、:5个观察指标各自A、B组治疗前后比较,差异均有统计学意义(P<0.001);治疗后2、4、6周末各时间点上的评分差异均有统计学意义(P<0.010或P<0.001);5个观察指标B组评分均较A组减低更明显。结论:联合黛力新治疗伴有情感障碍CTH较单用常规止痛剂效果好。关键词黛力新;情感障碍;慢性紧张型头痛STUDYONTHETHERAPEUTICEFFECTOFADMINISTERINGCOMBINEDWITHDEANXITINCHRONICTENSION-TYPEHEADACHEPATIENTSACCOMPANYINGAF-FECTIVEDISORDERLIUGu
3、ang-Jian,WANGYun-Fu,LIUYong,LUOGuo-Jun,HEGuo-Hou(DepartmentofNeurology,TaiheHospital,YunyangMedicalCollege,Shiyan,Hubei442000)AbstractObjective:ToestimatethecurativeeffectofadministeringcombinedwithDeanxitinchronictension-typeheadachepatientsaccompanyingaffectivedisorder.Methods:60patie
4、ntswererandomlydi-videdintogroupA(treatedwithparacetamolandchlorzoxazonedispersible,tiapride),andgroupB(treatedwithparacetamolandchlorzoxazonedispersible,tiaprideanddeanxit).Thecourseoftreatmentwas6weeks.Onthetimepointsofpre-treatmentand2,4,6weeksendofpost-treatment,theheadachedegree(HD
5、),weeklyparoxysmfrequency(WPF),sustainedtimeofparoxysm(STP)atatime,hamil-tonratingscaleforanxiety(HAMA)andhamiltonratingscalefordepression(HAMD)wererecorded.Results:Theabove5observingindexesbetweengroupAandgroupB,onpre-treatmentandpost-treat-mentwerereachedstatisticalsignificancediffere
6、nces(P<0.001).Andthescoresofthe5observingin-dexesbetweengroupAandgroupBonthetimepointsof2,4,6weeksendpost-treatmentwasalsoreachedstatisticalsignificancedifferences(P<0.010orP<0.001).Itwasfoundthatthescoresofall5observingindexesofgroupBhadbeenloweredmorethanthoseingroupA.Conclusion:InCTH
7、pa-tientswithaffectivedisorder,thetherapeuticeffectofadministeringcombinedwithDeanxitwasbetterthanthatoftreatmentwithgeneralanalgesicsalone.KeywordsDeanxit;Affectivedisorder;Chronictension-typeheadache慢性紧张型头痛(ChronicTension-typeHead-疗的基础上联合黛力新进行对比观察,通过对患者ache,CTH)约占临床头痛患者40%。临床
