组蛋白甲基化.pdf

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1、SnapShot:HistoneLysineMethylaseComplexesManMohan,Hans-MartinHerz,andAliShilatifardStowersInstituteforMedicalResearch,KansasCity,MO64110,USAYeastBiochemical/MethylaseSubstrateDrosophilaMammals(S.cerevisiae)biologicalpropertiesSUV39H1/2SETDB1SETDB1Su(var)3-9G9aATF7IPCAF1HeterochromatinKMT

2、1H3K9NotdetectedKMT1A/BHP1formation/silencingKMT1A/BKMT1CKMT1EG9AGLPKMT1C/DAsh2Cxxc1ASH2CXXC1Dpy30Ash2DPY30TrxDpy30MLL1/2RBBP5ASH2Rbbp5DPY30Mnn1WdsSet1MEN1WDR5Cps40Wdr82Rbbp5SET1A/BRBBP5WdsKMT2A/BKMT2A/BWDR82WDR5Activetranscription;Cps60KMT2F/GhomeoticgeneKMT2H3K4Cps25Ash2HCF1ASH2KMT2F/

3、Gexpression;nuclearSet1LptCps35Cps50HcfDpy30UTXDPY30hormonereceptorCps30UtxTrrRbbp5PA1MLL3/4RBBP5signalingPa1PTIPWDR5PtipWdsNCOA6KMT2C/DKMT2C/DySet1/COMPASSDrosophilaCOMPASSFamilyMammalianCOMPASSFamilySet2Set2Mes-4SET2WHSC1KMT3H3K36ActivetranscriptionCTDRNAPolIICTDRNAPolIICTDRNAPolIIKMT

4、3AKMT3AKMT3AKMT3BAF10AF9Dot1GrappaDOT1Activetranscription;KMT4H3K79TRRAPENLcell-cycleregulation;AF17WntsignalingKMT4KMT4KMT4DotComPR-Set7Su(var)4-20PR-Set7SUV4-20H1/H2TranscriptionalKMT5H4K20Notdetectedrepression;DNAdamageresponseKMT5AKMT5B/CKMT5AKMT5B/CSu(z)12SUZ12RBBP4/Nurf55Esc/RBBP7

5、EZH1/EEDE(z)EsclEZH2Polycombsilencing;XchromosomeKMT6H3K27NotdetectedAEBP2JARID2inactivation;cellfatedeterminationJingPclJarid2PHF1MTF2PHF19KMT6KMT6S-adenosyl-L-methionineS-adenosyl-L-methionineS-adenosyl-L-methionineCH3CH3CH3CH3CH3CH3KMTKMTKMTMonomethylation(me)Dimethylation(me2)Trimet

6、hylation(me3)498Cell149,April13,2012©2012ElsevierInc.DOI10.1016/j.cell.2012.03.025Seeonlineversionforlegendandreferences.SnapShot:HistoneLysineMethylaseComplexesManMohan,Hans-MartinHerz,andAliShilatifardStowersInstituteforMedicalResearch,KansasCity,MO64110,USALysinemethyltransferases(KM

7、Ts)catalyzethetransferofone,two,orthreemethylgroupsfromS-adenosyl-L-methionine(SAM)totheε-aminogroupofalysineresidueonahistonetogeneratemono-,di-,andtrimethylatedhistones.KMTsexisteithersinglyorwithincomplexes,inwhichthemembersofeachcomplexmodulatetheactivityoftheenzymes.KMTsha