总维生素D检测的重要性及临床意义.ppt

《总维生素D检测的重要性及临床意义.ppt》由会员上传分享，免费在线阅读，更多相关内容在PPT专区-天天文库。

1、1血清总25OH维生素D检测的重要性及临床应用TheImportanceandClinicalApplicationofTotal25OH-D维生素D营养状况的评判标准聊城地区育龄女性VD状况统计成人共636人VD<1026341.35%10≤VD<2031349.21%20≤VD<30375.82%VD≥30233.62%聊城地区儿童VD状况儿童统计364人VD<10113.02%10≤VD<206517.86%20≤VD<3013035.71%VD≥3015843.41%5维生素D的内分泌、旁分泌和自分泌功能维生素D在钙平衡中的作用维生素D可减低自身免疫性疾病发病率Vitam

2、inDsupplementationisassociatedwithalowerriskofautoimmunediseases.InaFinnishbirthcohortstudyof10,821children,supplementationwithvitaminDat2000IU/dreducedtheriskoftype1diabetesbyapproximately78%,whereaschildrenwhowereatriskforricketshada3-foldhigherriskfortype1diabetes.Inacase-controlstudyof7mi

3、llionUSmilitarypersonnel,highcirculatinglevelsofvitaminDwereassociatedwithalowerriskofmultiplesclerosis.SimilarassociationshavealsobeendescribedforvitaminDlevelsandrheumatoidarthritis.维持充足的维生素D水平可以减低多种自身免疫病的发病风险AprospectivecohortstudyofchildrenborninFinlandduringtheyear1966andfollowedforthir

4、tyyearsfoundthatthosewhoreceivedsupplementalvitaminDduringthefirstyearoflifehadasignificantlylowerriskofdevelopingIDDMArecentcase-controlstudyinU.S.militarypersonnel,including257casesofdiagnosedMS,foundthatwhitesubjectsinthehighestquintileofserum25-hydroxyvitaminD(>99.1nmol/L)hada62%lowerrisk

5、ofdevelopingMS.postmenopausalwomenwiththehighesttotalvitaminDintakeswereatsignificantlylowerriskofdevelopingRAafter11yearsoffollow-upthanthosewiththelowestintakes多发性硬化症与纬度的关系PeoplelivingclosertotheequatorareatdecreasedriskofdevelopingMSSimilartrends:cancer,hypertension促进细胞分化、抑制增殖---维生素D降低肿瘤发生

6、率TheactiveformofvitaminD,1,25-dihydroxyvitaminD,inhibitsproliferationandstimulatesthedifferentiationofcells.HolickMF.VitaminD:importanceinthepreventionofcancers,type1diabetes,heartdisease,andosteoporosis.AmJClinNutr.2004;79(3):362-371.促进细胞分化、抑制增殖---维生素D降低肿瘤发生率12VitDandDiseaseBrain：——精神分裂症sch

7、izophrenia——抑郁症depressionLung：——哮喘AsthmaCirculation：——高血压Hypertension——冠心病CHD——中风StrokeImmunosystem:——I型糖尿病DM——多发性硬化症MS——风湿性关节炎RH——可降低结核、流感活其他感染性疾病的临床症状TBetc.infectiondisease肿瘤Tumor：——乳腺癌(breast)——前列腺癌(prostate)——结肠癌(colon)——卵巢癌(ovary)骨骼与肌肉Mu