黄芪甲苷肾保护作用机制.pdf

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1、中华肾病研究电子杂志2013年8月第2卷第4期ChinJKidneyDisInvest(ElectronicEdition)，August2013．v01．2，No．4·39··综述·黄芪甲苷肾保护作用机制桂定坤汪年松【摘要】黄芪甲苷IV(As．IV)是黄芪的主要活性成分之一，As—IV。肾保护作用及机制目前尚未完全阐明。笔者对As—IV肾保护作用及其分子机制的相关研究进行了综述。As·IV能上调oL3B1整合素及抑制整合素连接酶表达，从而改善高糖诱导的足细胞粘附功能失调；还可通过抗氧化、恢复Bax

2、／Bc1．2表达平衡及抑制Caspase一3激活，从而防治糖尿病肾病足细胞凋亡；可抑制核因子一KB(NF—KB)介导的炎症基因表达，防治缺血性急性肾损伤(AKI)；可恢复Bax／Bcl一2表达平衡及抑制Caspase．3和磷酸化p38MAPK过度激活，从而防治缺血性及造影剂肾病和肾小管细胞凋亡；可调节细胞骨架蛋白，减轻补体膜攻击复合物诱导的足细胞损伤，可能被用于治疗膜性肾病。因此，AS．IV可能成为防治肾脏病的新型药物。【关键词】黄芪甲苷；糖尿病肾病；急性肾损伤；膜性肾病；机制Renalprotec

3、tiveefectsandmechanismsofastragalosideIVGU／Ding—song，WANGNian—song．DepartmentofNephrology，SixthPeopleSHospitalAffiliatedtOShanghaiJiaoTongUniversitySchoolofMedicine，Shanghai200233，ChinaCorrespondingauthor：WANGNian—song，Email：wangniansong2012@163．con【Ab

4、stract】AstragalosideIV(AS—IV)isoneofthemajoractivecomponentsoftheastragalusmembranaceus(Fisch)Bge．ItwasreportedthatAS—IVamelioratedischemia—reperfusioninjuryinbrainandheart，however，itsrenalprotectiveeffectsandmechnismshavenotbeenfullyinvestigatedyet．In

5、thispaper，wehavereviewedtherenalprotectiveeffectsandthemolecularmechanismsofAS—IV．AS·IVimprovedhighglucose—inducedpodocyteadhesiondysfunction．whichwaspartlyattributedto0【3131integrinupregulationandintegrin—linkedkinase(ILK)inhibition．Asanovelantioxidan

6、t，AS—IValsopreventedglucose-·inducedpodocyteapoptosispartlythroughrestoringthebalanceofandBcelllymphoma／leukemia-2(Bcl一2)andBcl-2一associatedXprotein(Bax)expressionandinhibitingcaspase一3activation．Moreover，AS-IVpreventedischemicacutekidneyinjury(AKI)thr

7、oughinhibitionofnuclearfactorK—light—chain—enhancerofactivatedBcells(NF—KB)mediatedinflammatorygenesexpression．AS—IValsopreventedrenaldysfunction，tubularinjury，andapoptosisinischemicandcontrast-inducedAKImodelsthroughrestoringthebalanceofBax／Bcl-2expre

8、ssionandinhibitingcaspase一3andp38mitogen·-activatedproteinkinase(MAPK)activation．AS—IVrestoredpodocytemorphologyandcytoskeletonlossinducedbycomplementmembraneattackcomplexSOthatAS—IVmightbeusedtotreatmembranousnephropathy．Therefore，AS—I