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《结直肠癌中COX I和COXⅢ的表达及临床意义.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、临床与实验病理学杂志JClinExpPathol2014Oct;30(10)网络出版时间:2014一lO一2308:25网络出版地址:http://www.cnki.net/kcms/doi/10.13315/j.cnki.cjcep.2014.10.005.html结直肠癌中COXI和coxm的表达及临床意义孟媛,宋敏,许斌摘要:目的观察线粒体细胞色素c氧化酶I(cytochromecoxidaseI,COXI)和线粒体细胞色素C氧化酶llI(cytoehromecoxidaseⅢ,coxm)在正常结直肠黏膜、结直肠高
2、级别上皮内瘤变(原位癌)和结直肠癌组织中的表达,探讨coxI和COXIII在结直肠癌早期诊断中的作用以及二者与结直肠癌患者预后的关系。方法采用免疫组化sP法检测20例结直肠正常黏膜、20例结直肠高级别上皮内瘤变(原位癌)和80例结直肠癌组织中COXI和COXm的表达,并分析二者表达与结直肠癌临床病理特征及患者预后的关系。结果coxI和coxlli在正常结直肠黏膜中的阳性率分别为75.0%(15/20)和70.0%(14/20),在结直肠高级别上皮内瘤变(原位癌)组织中的阳性率为35.0%(7/20)和25.0%(5/20
3、),在结直肠癌组织中的阳性率为36.2%(29/80)和26.2%(21/80);COXI和COXm在正常结直肠黏膜和结直肠高级别上皮内瘤变(原位癌)中的阳性率差异有统计学意义(x。=6.465,尸=0.011;)(。=8.120,P=0.004),COXI和coxm在正常结直肠黏膜和结直肠癌组织中的阳性率差异有统计学意义(x:9.75,P:o.002;)(=13.46,P4、COXⅢ的阳性率与结直肠癌临床分期相关,Ⅲ+Ⅳ期结直肠癌组中COXIU阳性率低于I+Ⅱ期组。Kaplan—Meier生存分析表明COXI和COXllI表达与结直肠癌患者预后相关(P=0.008,P=0.017)。结论COXI和COXm高表达与结直肠癌组织学分级、临床分期、预后密切相关,联合检测二者表达可作为结直肠癌早期诊断及判断其生物学行为的重要指标。关键词:结直肠肿瘤;细胞色素c氧化酶I;细胞色素c氧化酶il;免疫组织化学中图分类号:R735.3文献标志码:A文章编号:1001—7399(2014)10—1094—055、doi:10.13315/j.cnki.cjcep.2014.10.005ExpressionofCOXIandC0XmandtheirsignificanceincolorectalcancerMENGYuan,SONGMin,XUBin(DepartmentofPathology,FushunCentralHospital,Fushun113006,China;DepartmentofPathology,theFirstAffiliatedHospital0厂ChinaMedicalUniversity,Shenya6、ng110001,China)Abstract:PurposeToinvestigatetheexpressionlevelsofcytochromecoxidaseI(COXI)andcytochromeeoxidasem(coxm)incolorecta!cancerandtheirrelationshipswiththeoecureuce,development,andprognosisofeolorectalcancer.MethodsTheim—munohistochemicalSPmethodwasusedt7、odetecttheexpressionoftheCOXIandCOXllIproteinsincolorectaltissue.ThecorrelationsofCOXIandCOXⅢwithc1inic0pathologicfeatureswereanalyzedineoloreetalcancer.ResultsThepositiveratesofCOXIandCOXⅢexpressionwere75.0%(15/20)and70.O%(14/20)innormalcolorectaltissue,35.0%(7/8、20)and25.0%(5/20)incolorectalseveredyaplasiatissuesand,36.2%(29/80)and26.2%(21/80)incoloreetalcancertissues,respectively.Theexpres—sionratesoftheCOX1andCOXll1w
4、COXⅢ的阳性率与结直肠癌临床分期相关,Ⅲ+Ⅳ期结直肠癌组中COXIU阳性率低于I+Ⅱ期组。Kaplan—Meier生存分析表明COXI和COXllI表达与结直肠癌患者预后相关(P=0.008,P=0.017)。结论COXI和COXm高表达与结直肠癌组织学分级、临床分期、预后密切相关,联合检测二者表达可作为结直肠癌早期诊断及判断其生物学行为的重要指标。关键词:结直肠肿瘤;细胞色素c氧化酶I;细胞色素c氧化酶il;免疫组织化学中图分类号:R735.3文献标志码:A文章编号:1001—7399(2014)10—1094—05
5、doi:10.13315/j.cnki.cjcep.2014.10.005ExpressionofCOXIandC0XmandtheirsignificanceincolorectalcancerMENGYuan,SONGMin,XUBin(DepartmentofPathology,FushunCentralHospital,Fushun113006,China;DepartmentofPathology,theFirstAffiliatedHospital0厂ChinaMedicalUniversity,Shenya
6、ng110001,China)Abstract:PurposeToinvestigatetheexpressionlevelsofcytochromecoxidaseI(COXI)andcytochromeeoxidasem(coxm)incolorecta!cancerandtheirrelationshipswiththeoecureuce,development,andprognosisofeolorectalcancer.MethodsTheim—munohistochemicalSPmethodwasusedt
7、odetecttheexpressionoftheCOXIandCOXllIproteinsincolorectaltissue.ThecorrelationsofCOXIandCOXⅢwithc1inic0pathologicfeatureswereanalyzedineoloreetalcancer.ResultsThepositiveratesofCOXIandCOXⅢexpressionwere75.0%(15/20)and70.O%(14/20)innormalcolorectaltissue,35.0%(7/
8、20)and25.0%(5/20)incolorectalseveredyaplasiatissuesand,36.2%(29/80)and26.2%(21/80)incoloreetalcancertissues,respectively.Theexpres—sionratesoftheCOX1andCOXll1w
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