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时间:2020-05-07
《化疗联合冷循环射频消融术治疗原发性肝癌的效果分析-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·5700·现代生物医学进展www~shengwuyixue.eomProgressinModernBiomedicineVoL13NO.29OCT.2013化疗联合冷循环射频消融术治疗原发性肝癌的效果分析赵丹懿张阳△李曼奇李娜(大连医科大学附属第二医院肿瘤内科辽宁大连116023)摘要目的:探讨化疗联合冷循环射频消融术治疗原发性肝癌的疗效及安全性。方法:108例原发性肝癌患者随机分为两组,均给予灌注化疗,每4周进行一次灌注化疗,对照组(n=54)进行3次,治疗组(n=54)X进行一次。治疗组给予冷循环射频消融术。
2、评价生活质量Kamofsky评分,治疗前后检查患者的血、尿、便常规,肝肾功能(包括天冬氨酸转氨酶、丙氨酸转氨酶(bET)、白蛋白(ALB)、总胆红素、肌酐及尿素氮等指标),甲胎蛋白(AFP),T细胞亚群和加强肝脏CT扫描。随访1年,经CT确定肝癌复发。结果:治疗组Karnofsky评分有效率为59.26%,对照组Karnofsky评分有效率为37.03%,两组Kamofsky评分有效率相比较,差异有统计学意义(P<0.05)。两组治疗后症状变化相比较,除腹胀外其余各项指标差异均有统计学意义(P3、组相比较,ALT和AFP差异有统计学意义(P<0.05)。治疗后两组T细胞亚群变化相比较,治疗组各项指标均变化显著(P4、inicalStudyofChemotherapyCombinedwithCool—tipRadiofrequencyAblationinTreatingPrimaryLiverCancerZHAODan-yi,ZHANGYan,LIMan—qi,LINa(Medicaloncology,theSecondAffiliatedHospitalofDalianMech'calUniversity,Liaoning,Dalian,116023,China)ABSTRACTObjective:Tostudyandinve5、stigatethecurativeefectandsecurityofchemotherapycombinedwithcool—tipradiofrequencyablationintreatmentofprimarylivercancer.Methods:108patientswithprimarylivercancerwererandomlydividedintotwogroupsandbothgroupsweregiveninfusionchemotherapyonetimeeveryfourweeks.T6、hecontrolgroup(n54)wastreatedfor3ti—rues,whilethetreatmentgroup(n=54)wastreatedonlyforonce.Treatmentgroupwasalsogivencool—tipradiofequencyablation.weevaluatedthequalityoflifebyKamofskyscores,anddetectedthepatient’sblood,urine,stoolroutineexamination,liverandki7、dneyfunction(includingindexeslikeaspartateaminotransferase,alanineaminotransferase(ALT),albumin(ALB),totalbilirubinandcreatinineandureanitrogen),alphafetoprotein(AFP)andTcellsubsets,andstrengthenliverCTscansbeforeandaftertreatment.CTwasusedtodeterminelivercanc8、errecurrenceduringthefollow·up1yearlater.Results:TheefectiverateofKarnofskyscorewas59.26%intreatmentgroup,andwas37.03%incontrolgroup,withstatisticallysignificantdiference(P<0.05).E
3、组相比较,ALT和AFP差异有统计学意义(P<0.05)。治疗后两组T细胞亚群变化相比较,治疗组各项指标均变化显著(P4、inicalStudyofChemotherapyCombinedwithCool—tipRadiofrequencyAblationinTreatingPrimaryLiverCancerZHAODan-yi,ZHANGYan,LIMan—qi,LINa(Medicaloncology,theSecondAffiliatedHospitalofDalianMech'calUniversity,Liaoning,Dalian,116023,China)ABSTRACTObjective:Tostudyandinve5、stigatethecurativeefectandsecurityofchemotherapycombinedwithcool—tipradiofrequencyablationintreatmentofprimarylivercancer.Methods:108patientswithprimarylivercancerwererandomlydividedintotwogroupsandbothgroupsweregiveninfusionchemotherapyonetimeeveryfourweeks.T6、hecontrolgroup(n54)wastreatedfor3ti—rues,whilethetreatmentgroup(n=54)wastreatedonlyforonce.Treatmentgroupwasalsogivencool—tipradiofequencyablation.weevaluatedthequalityoflifebyKamofskyscores,anddetectedthepatient’sblood,urine,stoolroutineexamination,liverandki7、dneyfunction(includingindexeslikeaspartateaminotransferase,alanineaminotransferase(ALT),albumin(ALB),totalbilirubinandcreatinineandureanitrogen),alphafetoprotein(AFP)andTcellsubsets,andstrengthenliverCTscansbeforeandaftertreatment.CTwasusedtodeterminelivercanc8、errecurrenceduringthefollow·up1yearlater.Results:TheefectiverateofKarnofskyscorewas59.26%intreatmentgroup,andwas37.03%incontrolgroup,withstatisticallysignificantdiference(P<0.05).E
4、inicalStudyofChemotherapyCombinedwithCool—tipRadiofrequencyAblationinTreatingPrimaryLiverCancerZHAODan-yi,ZHANGYan,LIMan—qi,LINa(Medicaloncology,theSecondAffiliatedHospitalofDalianMech'calUniversity,Liaoning,Dalian,116023,China)ABSTRACTObjective:Tostudyandinve
5、stigatethecurativeefectandsecurityofchemotherapycombinedwithcool—tipradiofrequencyablationintreatmentofprimarylivercancer.Methods:108patientswithprimarylivercancerwererandomlydividedintotwogroupsandbothgroupsweregiveninfusionchemotherapyonetimeeveryfourweeks.T
6、hecontrolgroup(n54)wastreatedfor3ti—rues,whilethetreatmentgroup(n=54)wastreatedonlyforonce.Treatmentgroupwasalsogivencool—tipradiofequencyablation.weevaluatedthequalityoflifebyKamofskyscores,anddetectedthepatient’sblood,urine,stoolroutineexamination,liverandki
7、dneyfunction(includingindexeslikeaspartateaminotransferase,alanineaminotransferase(ALT),albumin(ALB),totalbilirubinandcreatinineandureanitrogen),alphafetoprotein(AFP)andTcellsubsets,andstrengthenliverCTscansbeforeandaftertreatment.CTwasusedtodeterminelivercanc
8、errecurrenceduringthefollow·up1yearlater.Results:TheefectiverateofKarnofskyscorewas59.26%intreatmentgroup,andwas37.03%incontrolgroup,withstatisticallysignificantdiference(P<0.05).E
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