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时间:2020-05-07
《学龄期儿童肥胖相关性脂肪肝及血脂代谢异常对照研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、788中国儿童保健杂志2014年O8月第22卷第8期CJCHCAUG.2014,Vol22,N。.8·科研论著·学龄期儿童肥胖相关性脂肪肝及血脂代谢异常对照研究刘倩,陈虹,朱庆龄,叶新华,原新慧兰州大学第一医院,甘肃兰州730003摘要:目的探讨兰州市学龄期儿童肥胖非酒精性脂肪肝(nonalcoholicfattyliverdisease,NAFLD)、血脂代谢异常及其相关因素。方法2011年6—1O月选取3所小学1至6年级7~l4岁小学生作为研究对象。选取年龄、性别匹配体质指数(bodymassindex,BMI)正常儿童作为对照。行腹部B超、采空腹静脉血
2、5ml进行实验室检查,包括天冬氨酸氨基转移酶(aspartateaminotransferase,AST)、丙氨酸氨基转移酶(alanineaminotransferase,AIT)、谷氨酰转肽酶(gammaglutamyltranspeptidase,GGT)、总胆固醇(totalcholesterol,CH0L)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high—densitylipoproteincholesterol,HDL—c)、低密度脂蛋白胆固醇(1owdensitylipoproteincholesterol,LDI一c
3、)。结果筛查出肥胖儿童8O例,与51例正常对照儿童比较,肥胖组儿童的AST、ALT、GGT、CHOI、TG、IDL—C增高,HDI一C减低,差异有统计学意义(P4、童的肝功能损害、血脂代谢异常甚至可造成非酒精性脂肪肝的发生;非酒精性脂肪肝更进一步加重了肝功能损害及血脂代谢紊乱。关键词:肥胖;非酒精性脂肪肝;血脂紊乱;学龄儿童中图分类号:R723.14文献标识码:A文章编号:1008—6579(2O14)080788—03doi:10.11852/zgetbjzz20l4-22-08—02Case-controlstudyonschool-agedchildrenobesitycorrelationbetweenfattyliverandbloodlipidmetabolicabnormalities.LIUQian,C5、HENHong,ZHUQing—ling,YEXinhua,yUANXin—hui.(1eFirstHospitalofLanzhouUniversity,Lanzhou,Gansu730003,China)C0rrPs0gauthor:CHENHong,E-mail:ch701(163.C017lAbstract:ObjectiveTostudythenonalcoholicfattyliverdisease(NAFID)andbloodlipidmetabolismanditsrelat—edfactorsinschool—agedobesitychil6、dreninLanzhou.MethodsGrades1~6pupilsaged7to14wereselectedfrom3schools.BM1werechosenasnormalcontro1.Abdominalultrasoundwastaken,and5mIfastingvenousbloodsampleswascollectedtodetectaspartateaminotransferase(AST),alanineaminotransferase(AIT),gammaglutamyltranspeptidase(GGT),totalcholes7、terol(CHOL),triglyceride(TG),high—densitylipoproteincholesterol(HDI一C)andlowdensitylipo—proteincholesterol(LDI一C).ResuitsAtota1of80obesechildrenweredetectedfrom3000children.Comparedwith51normalcontrols,AST,ALT,GGT,CHOL,TG,LDI一CwerehigherwhileHDL—Cwas1owerinobesechildren(P8、,AIT,GGT,TG,LDL—Castherisk
4、童的肝功能损害、血脂代谢异常甚至可造成非酒精性脂肪肝的发生;非酒精性脂肪肝更进一步加重了肝功能损害及血脂代谢紊乱。关键词:肥胖;非酒精性脂肪肝;血脂紊乱;学龄儿童中图分类号:R723.14文献标识码:A文章编号:1008—6579(2O14)080788—03doi:10.11852/zgetbjzz20l4-22-08—02Case-controlstudyonschool-agedchildrenobesitycorrelationbetweenfattyliverandbloodlipidmetabolicabnormalities.LIUQian,C
5、HENHong,ZHUQing—ling,YEXinhua,yUANXin—hui.(1eFirstHospitalofLanzhouUniversity,Lanzhou,Gansu730003,China)C0rrPs0gauthor:CHENHong,E-mail:ch701(163.C017lAbstract:ObjectiveTostudythenonalcoholicfattyliverdisease(NAFID)andbloodlipidmetabolismanditsrelat—edfactorsinschool—agedobesitychil
6、dreninLanzhou.MethodsGrades1~6pupilsaged7to14wereselectedfrom3schools.BM1werechosenasnormalcontro1.Abdominalultrasoundwastaken,and5mIfastingvenousbloodsampleswascollectedtodetectaspartateaminotransferase(AST),alanineaminotransferase(AIT),gammaglutamyltranspeptidase(GGT),totalcholes
7、terol(CHOL),triglyceride(TG),high—densitylipoproteincholesterol(HDI一C)andlowdensitylipo—proteincholesterol(LDI一C).ResuitsAtota1of80obesechildrenweredetectedfrom3000children.Comparedwith51normalcontrols,AST,ALT,GGT,CHOL,TG,LDI一CwerehigherwhileHDL—Cwas1owerinobesechildren(P8、,AIT,GGT,TG,LDL—Castherisk
8、,AIT,GGT,TG,LDL—Castherisk
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