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时间:2020-05-03
《丙肝相关性肝癌根治术后复发规律及危险因素分析-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第23卷第1期中国普通外科杂志Vo1.23No.12014年1月ChineseJournalofGeneralSurgeryJan.2014doi:10.7659/j.issn.1005—6947.2014.01.005·肝肿瘤专题研究·http://www.zpwz.net/CN/abstract/abstract3751.shtml丙肝相关性肝癌根治术后复发规律及危险因素分析丁同领,赵新2,肖朝辉,余灵祥。,乐羿。,洪智贤,张绍庚(1.福建医科大学福州总医院临床医学院肝胆外科,福建福州350025;2.中国人民解
2、放军第三O二医院肝胆外科,北京100039)摘要目的:分析丙肝相关性肝癌(HCV.HCC)根治术后复发规律及相关危险因素,探讨针对复发时相的个体化临床干预。方法:回顾98例行HCV.HCC根治术的患者临床病理资料,分析患者根治术后复发规律,对复发的可能影响因素进行单因素及多因素分析,并对病毒因素进行分层分析。结果:全组根治术后有2个复发高峰,以24个月为界分为早、晚期;COX比例风险模型分析显示,肿瘤低分化、镜下微血管侵犯为术后早期复发的独立危险因素(P3、);术后病毒载量持续阴性患者无瘤生存期明显长于术后持续高病毒载量或病毒载量不稳定者(P4、erradicaIresectionandtheriskfactorsDINGTongling。,ZHAOXin,XIAOZhaohui,YULingxiang,LEYi,HONGZhixian,ZHANGShaogeng‘'fI.DepartmentofHepatobiliarySurge~ClinicalMedicineSchool,FuzhouGeneralHospital,FufianMedicalUniversity,Fuzhou350025,China2.DepartmentofHepatobiliary5、Surgery,the302MilitaryHospitalofChina,Beijing100039,China)Correspondingauthor:ZHANGShaogeng,Email:zhang.sg@medmail.corn.cnABSTRACTObjective:ToanalyzetherecurrenceprofilesofthehepatitisCvirus—relatedhepatocellularcarcinoma(HCV-HCC)afterradicalresectionandtherisk6、factorsJanddiscusstheindividualizedclinicalinterventionsfordiferentrecurrentphases.Methods:Theclinicopathologicdataof98HCV-HCCpatientsundergoingradicalresectionwerereviewed.Therecurrenceprofilesofthesepatientsafterradicalresectionwereanalyzed,andtheriskfactorsf7、orrecurrenceweredeterminedbybothunivariateandmultivariateanalysis.Moreove~theviralfactorwasevaluatedusingstratifiedanalysis.Results:TwopeaksofrecurrenceafterradicalresectionwereobservedintheentiregroupofpatientsJanddemarcationpointbetweentheearlyandlaterecurren8、cewasatpostoperative24months.COXproportional收稿日期:2013—08—06;修订日期:2013—12—12。作者简介:丁同领,福建医科大学福州总医院临床医学院硕士研究生,主要从事肝胆外科方面的研究。通信作者:张绍庚,Email:zhang.sg@medmail.com.cn@皈衩妇中国普通外科杂志昕南
3、);术后病毒载量持续阴性患者无瘤生存期明显长于术后持续高病毒载量或病毒载量不稳定者(P4、erradicaIresectionandtheriskfactorsDINGTongling。,ZHAOXin,XIAOZhaohui,YULingxiang,LEYi,HONGZhixian,ZHANGShaogeng‘'fI.DepartmentofHepatobiliarySurge~ClinicalMedicineSchool,FuzhouGeneralHospital,FufianMedicalUniversity,Fuzhou350025,China2.DepartmentofHepatobiliary5、Surgery,the302MilitaryHospitalofChina,Beijing100039,China)Correspondingauthor:ZHANGShaogeng,Email:zhang.sg@medmail.corn.cnABSTRACTObjective:ToanalyzetherecurrenceprofilesofthehepatitisCvirus—relatedhepatocellularcarcinoma(HCV-HCC)afterradicalresectionandtherisk6、factorsJanddiscusstheindividualizedclinicalinterventionsfordiferentrecurrentphases.Methods:Theclinicopathologicdataof98HCV-HCCpatientsundergoingradicalresectionwerereviewed.Therecurrenceprofilesofthesepatientsafterradicalresectionwereanalyzed,andtheriskfactorsf7、orrecurrenceweredeterminedbybothunivariateandmultivariateanalysis.Moreove~theviralfactorwasevaluatedusingstratifiedanalysis.Results:TwopeaksofrecurrenceafterradicalresectionwereobservedintheentiregroupofpatientsJanddemarcationpointbetweentheearlyandlaterecurren8、cewasatpostoperative24months.COXproportional收稿日期:2013—08—06;修订日期:2013—12—12。作者简介:丁同领,福建医科大学福州总医院临床医学院硕士研究生,主要从事肝胆外科方面的研究。通信作者:张绍庚,Email:zhang.sg@medmail.com.cn@皈衩妇中国普通外科杂志昕南
4、erradicaIresectionandtheriskfactorsDINGTongling。,ZHAOXin,XIAOZhaohui,YULingxiang,LEYi,HONGZhixian,ZHANGShaogeng‘'fI.DepartmentofHepatobiliarySurge~ClinicalMedicineSchool,FuzhouGeneralHospital,FufianMedicalUniversity,Fuzhou350025,China2.DepartmentofHepatobiliary
5、Surgery,the302MilitaryHospitalofChina,Beijing100039,China)Correspondingauthor:ZHANGShaogeng,Email:zhang.sg@medmail.corn.cnABSTRACTObjective:ToanalyzetherecurrenceprofilesofthehepatitisCvirus—relatedhepatocellularcarcinoma(HCV-HCC)afterradicalresectionandtherisk
6、factorsJanddiscusstheindividualizedclinicalinterventionsfordiferentrecurrentphases.Methods:Theclinicopathologicdataof98HCV-HCCpatientsundergoingradicalresectionwerereviewed.Therecurrenceprofilesofthesepatientsafterradicalresectionwereanalyzed,andtheriskfactorsf
7、orrecurrenceweredeterminedbybothunivariateandmultivariateanalysis.Moreove~theviralfactorwasevaluatedusingstratifiedanalysis.Results:TwopeaksofrecurrenceafterradicalresectionwereobservedintheentiregroupofpatientsJanddemarcationpointbetweentheearlyandlaterecurren
8、cewasatpostoperative24months.COXproportional收稿日期:2013—08—06;修订日期:2013—12—12。作者简介:丁同领,福建医科大学福州总医院临床医学院硕士研究生,主要从事肝胆外科方面的研究。通信作者:张绍庚,Email:zhang.sg@medmail.com.cn@皈衩妇中国普通外科杂志昕南
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