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1、BreastCancerResTreat(2010)122:471–481DOI10.1007/s10549-009-0690-9EPIDEMIOLOGYFactorsinfluencingtheassociationbetweenCYP17T34Cpolymorphismandtheriskofbreastcancer:meta-regressionandsubgroupanalysisYunChen•JianpingPeiReceived:11December2009/Accepted:12December2009/Publishedonline:31
2、December2009ÓSpringerScience+BusinessMedia,LLC.2009AbstractAnumberofstudieshavebeeninvestigatedthebirth,parity,useoforalcontraceptives,bodymassindexassociationbetweenCYP17T34Cpolymorphismandthe(BMI),anduseofhormonerepairtherapy(HRT).Afterriskofbreastcancer;theresultsofthesestudie
3、sarethesepopulationstratifications,therewasevidenceindi-inconsistent,however.Thisfactimpliesthattheeffectofcatingthatapossibleimpactofmenopausalstatus,ageatCYP17T34Cpolymorphismonsusceptibilitytobreastmenarche,andBMIontheassociationbetweenCYP17cancermaybemodifiedbyotherriskfactors.
4、InordertoT34Cpolymorphismandtheriskofbreastcancer.provideamoredefinitiveconclusion,afullmeta-analysiscombiningandsummarizing24studieswasfirstper-KeywordsCYP17PolymorphismBreastcancerformed.BothtraditionalmethodandBayesianapproachBayesianmeta-regressionSubgroupmeta-analysiswerea
5、pplied.Oddsratiowasestimatedusingadominantmodeofinheritanceafterabiologicaljustificationforthechoiceofgeneticmodel.TheresultsofhomogeneityIntroduction2analysis(H=1.16,I=25.4%,andP=0.127)sug-gestedthepresenceofheterogeneityacrossthestudies.Breastcanceristhesecondleadingcauseofcance
6、rdeathsThus,randomeffectsmodelssimulatedbytheDerSimo-inwomentoday.Exposuretocirculatingestrogenhasbeennian–Lairdmethodwereemployed.ThecapabilityofawidelyacceptedasanimportantfactorfortheriskofbreastBayesianapproachwashighlightedintheestimationofacancer.Sinceestrogenbiosynthesisan
7、dmetabolismconsistpooledoddsratioand95%confidenceinterval.Theresultsofmanytranslationandtranscriptionsteps,thegenesofmeta-analysis(OR=1.001,CI=0.832–1.208)suggestinvolvedintheseprocessesmaycontributetothelevelofnosignificantassociationinthecombinedpopulations.estrogen,therebytheinh
8、erentvariabilityinsusceptibilityFurtherm
