细胞色素p45017α羟化酶

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1、BreastCancerResTreat(2010)122:471–481DOI10.1007/s10549-009-0690-9EPIDEMIOLOGYFactorsinfluencingtheassociationbetweenCYP17T34C polymorphismandtheriskofbreastcancer:meta-regression andsubgroupanalysisYunChen•JianpingPeiReceived:11December2009/Accepted:12Dece

2、mber2009/Publishedonline:31December2009ÓSpringerScience+BusinessMedia,LLC.2009AbstractAnumberofstudieshavebeeninvestigatedthebirth,parity,useoforalcontraceptives,bodymassindexassociationbetweenCYP17T34Cpolymorphismandthe(BMI),anduseofhormonerepairtherapy(

3、HRT).Afterriskofbreastcancer;theresultsofthesestudiesarethesepopulationstratifications,therewasevidenceindi-inconsistent,however.Thisfactimpliesthattheeffectofcatingthatapossibleimpactofmenopausalstatus,ageatCYP17T34Cpolymorphismonsusceptibilitytobreastmen

4、arche,andBMIontheassociationbetweenCYP17cancermaybemodifiedbyotherriskfactors.InordertoT34Cpolymorphismandtheriskofbreastcancer.provideamoredefinitiveconclusion,afullmeta-analysiscombiningandsummarizing24studieswasfirstper-formed.BothtraditionalmethodandBaye

5、sianapproachwereapplied.OddsratiowasestimatedusingadominantmodeofinheritanceafterabiologicaljustificationfortheKeywordsCYP17PolymorphismBreastcancerBayesianmeta-regressionSubgroupmeta-analysischoiceofgeneticmodel.Theresultsofhomogeneityanalysis(H=1.16,I2=2

6、5.4%,andP=0.127)sug-Introductiongestedthepresenceofheterogeneityacrossthestudies.BreastcanceristhesecondleadingcauseofcancerdeathsThus,randomeffectsmodelssimulatedbytheDerSimo-inwomentoday.Exposuretocirculatingestrogenhasbeennian–Lairdmethodwereemployed.T

7、hecapabilityofawidelyacceptedasanimportantfactorfortheriskofbreastBayesianapproachwashighlightedintheestimationofacancer.Sinceestrogenbiosynthesisandmetabolismconsistpooledoddsratioand95%confidenceinterval.Theresultsofmanytranslationandtranscriptionsteps,t

8、hegenesofmeta-analysis(OR=1.001,CI=0.832–1.208)suggestinvolvedintheseprocessesmaycontributetothelevelofnosignificantassociationinthecombinedpopulations.estrogen,therebytheinherentvariabilityinsusceptibilityFurthermor