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1、复方苦参注射液联合同步放化疗治疗局部晚期胃癌近期临床观摘要:目的观察复方苦参注射液联合同步放化疗治疗局部晚期胃癌的近期临床效果。方法将65例局部晚期胃癌初治患者随机分为治疗组33例和对照组32例。对照组采用适形调强放疗同步卡培他滨化疗,治疗组在对照组基础上同时给予复方苦参注射液20mL/次,1次/d,连续5周。观察2组患者近期疗效、生活质量、不良反应。结果治疗组近期疗效有效率为66.67%(22/33),对照组为40.63%(13/32),差异有统计学意义(P=0.031)o血液毒性不良反应中,治疗组白细胞下降发生率为30.30%(10/33),对照组为65.63%(21/32),
2、差异有统计学意义(P=0.004)o治疗组卡氏评分升高26例(78.79%),对照组升高18例(56.25%),差异有统计学意义(P=0・046)。结论复方苦参注射液联合同步放化疗治疗局部晚期胃癌近期效果较好,可减轻不良反应、改善生活质量。关键词:局部晚期胃癌;化学疗法;适形调强放疗;复方苦参注射液D0I:10.3969/j.issn.1005-5304.2016.10.009中图分类号:R273.52文献标识码:A文章编号:1005-5304(2016)10-0035-03Abstract:ObjectiveTostudytherecentclinicalefficacyofco
3、mpoundmatrineinjectionscombinedwithconcurrentchemoradiotherapyinthetreatmentoflocallyadvancedgastriecancer・MethodsTotally65casesofuntreatedlocallyadvancedgastriccancerwererandomlydividedintotreatmentgroup(33cases)andcontrolgroup(32cases)・Thecontrolgroupwastreatedbytheconformalintensitymodulate
4、dradiotherapycombinedwithchemotherapy.Onthebasisofthecorrtrolgroup,thetreatmentgroupwasgivencompoundmatrineinjections20mL/time,onceadayfor5weeks・Therecentcurativeeffect,thequalityoflifeandadversereactionofthetwogroupswereobserved・ResuItsTherecentcurativeeffectrateofthetreatmentgroupwas66.67%(2
5、2/33),thecontrolgroupwas40.63%(13/32),thedifferencewasstatisticallysignificant(P=0.031)・Onhematologictoxicity,leukopeniaoccurredinthetreatmentgroupwas30.30%(10/33),thecontrolgroupwas65.63%(21/32),thedifferencewasstatisticallysignificant(P二0.004)・KPSof26cases(78・79%)improvedinthetreatment,and18
6、cases(56.25%)improvedinthecontrolgroup・ConclusionTheeffectsofcompoundmatrineinjectionslocallycombinedwithconcurrentchemoradiotherapyfortheycanimproveadvancedgastriecanceraregood,andimproveshort-termefficacy,reducesideeffects,thequalityoflife.Keywords:locallyandvancedgastriecancer;chemotherapy;
7、intensitymodulatedradiotherapy;compoundmatrineinjections胃癌发病率居所有肿瘤的第4位,病死率居第3位。胃癌的发病和好发部位具有显著的地理差异,东亚地区为胃癌高发地区[llo早期诊断率低,大多数患者就诊时已发展至中晚期,手术切除率低,而全身化疗、放射治疗的综合治疗在中晚期胃癌的治疗中具有重要的作用O本研究观察复方苦参注射液联合同步放化疗对局部晩期胃癌患者的近期疗效及不良反应。1资料与方法1.1一般资料选取2014年