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时间:2020-04-20
《牛磺熊去氧胆酸与熊去氧胆酸对预防保胆术后结石复发的临床研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、史旦剑外科杂志2014年4月第l4卷第4期ChinJMinInvSu%Aoril2014.Vo1.14,N0.4临床论著·牛磺熊去氧胆酸与熊去氧胆酸对预防保胆术后结石复发的临床研究陈建飞赵期康李晋忠黄坤全刘京山(北京大学首钢医院普外科,北京100144)【摘要】目的评价牛磺熊去氧胆酸(TUDCA)与熊去氧胆酸(UDCA)对保胆取石术后患者预防胆囊结石复发的差异性及其临床价值。方法2010年lO月一2011年12月,我院内镜微创保胆手术成功的313例胆囊结石按病历号奇偶分为TUDCA组(=161)和UDCA组(n=152),术后2周T
2、UDCA组口服牛磺熊去氧胆酸胶囊(商品名:滔罗特,意大利贝斯迪大药厂生产,进口批文号:H20070200、H20110233)500mg,每晚1次,连续服用5天后,停药10天,l5天为一周期;UDCA组1:3服熊去氧胆酸胶囊(商品名:优思弗,德国Dr.Falk药厂生产,进1:3批文号H20050181)500mg,每晚1次。两组服药疗程均为18O天。两组术后护理、饮食等均相同。术后定期随访及复查B超,观察记录胆囊结石复发、胆囊壁厚度变化以及胆囊收缩率。结果2组随访时间12—30个月,TUDCA组和UDCA组2年胆囊结石复发率分别为3
3、.7%和12.4%(1og.rankX=5.304,P=0.021)。结论内镜微创保胆取石术后口服TUDCA预防胆囊结石的复发效果优于UDCA。【关键词】保胆取石术;结石复发;牛磺熊去氧胆酸中图分类号:R657.4文献标识:A文章编号:1009—6604(2014)04—0311一o3doi:10.3969/i.issn.1009—6604.2014.04.007AComparativeClinicalStudyfortheRelapseofCholelithiasisafterGallbladder-preservingLitho
4、tomybetweenTauroursodeoxycholicAcidandUrsodeoxycholicAcidChenfianfei,ZhaoQikang,LiJinzhong,eta1.DepartmentofGeneralSurgery,PekingUniversityShougangHospital,Beijing100144,China【Abstract】ObjectiveToevaluatetheclinicaleffectbetweentauroursodeoxycholicacid(TUDCA)andursodeo
5、xycholicacid(UDCA)onpreventingtherelapseofcholelithiasisaftergallbladder—preservinglithotomyviach0ledoch0scope.MethodsAtotalof313patientsofch0lecystolithi8sisinPekingUniversityShougangHospitalundergoinggallbladder—preservinglithotomyviacholed0ch0scopeweredividedintoTUD
6、CAandUDCAgroupbyoddandevennumbersoftheirmedicalrecord.TheTUDCAgrouptook500mgTUDCA(commodityname:Taurolite,BruschettiniS.r.1.,Italy,impo~approvalnumber:H20070200/H20110233)oncepernight,for5daysconsecutively,andwithdrewthedrugfor10days,15dayswasconsideredacycle;theUDCAgr
7、ouptook500mgUDCA(commodityname:Ursofalk,Dr.FalkPharmaGmbH,German,impo~approvalnumber:H20050181)oncepernight.Thetotalcourseoftreatmentofthetwogroupswas180d.Nursinganddiettherapieswerethesameinthetwogroups.TheeaseswerecheckedatregularintervalsaftersurgerywithBuhrasonogra
8、phyandwerefollowedup.Therecurrencerateofcalculi,thechangeofthethicknessofgallbladderwallandtherateofgallbladdercontra
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