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时间:2017-12-08
《吡格列酮对ⅱ型糖尿病并发冠心病患者血清视黄醇结合蛋白4的影响》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、·32O·西部医学2014年3月第26卷第3期MedJWestChina,March2014,Vo1.26,No.3吡格列酮对Ⅱ型糖尿病并发冠心病患者血清视黄醇结合蛋白4的影响张敏,陈树,陈平,曾庆翠,王钧康,任敏,孙勤,董巍。(四川省医学科学院·四川省人民医院1.老年科,2.中心实验室,四川成都610072)【摘要】目的观察吡格列酮对Ⅱ型糖尿病并发冠心痛(TzDM)患者血清视黄醇结合蛋白4(RBP4)的影响,并探讨其可能机制。方法随机选取T2DM合并冠心病患者6O例,正常对照组30例。分别检测血清RBP4、肿瘤坏死因子(TNF-a)、脂联素、空腹血糖(FPG)和胰岛素(Ins)、体重指数(B
2、MI)、血压(BP)、总胆固醇(TC)、甘油三酯(TG)等指标,计算胰岛素敏感指数(ISI)和胰岛素抵抗指数(H0MA—IR)。再将6O例T2DM并发冠心病患者分成吡格列酮治疗组28例和常规治疗组32例,吡格列酮治疗组用吡格列酮治疗8周,治疗前后均测定上述指标。结果①T2DM合并冠心病患者与对照组比较,血清RBP4水平增高(P<0.01);吡格列酮治疗组与常规治疗组比较,血清RBP4无差异(P>0.05)。②应用吡格列酮治疗后,患者血清RBP4水平显著降低(P3、管病患者血清RBP4水平,改善IR。【关键词】Ⅱ型糖尿病;冠心病;胰岛素抵抗;视黄醇结合蛋白4;吡格列酮【中图分类号】R587.1;R5414【文献标志码】Adoi:10.3969/].issn.1672-3511.2014.03.020Influenceofpioglitazoneonserumretinolbindingprotein4inpatientswithtype2diabetesmellitusaccompaniedwithCHDZHANGMin,CHENGShu,CHENGPing,etal(DepartmentofElderly;SichuanProvincePeople’H4、ospital,Chengdu610072)[Abstract]ObjectiveToobservetheeffectofpioglitazoneonserumretinolbindingprotein4(RBP4)inpatientswithtype2diabetesmellitusaccompaniedwithCHDandtentativelyexplorethemechanism.MethodsSixtypatientswithtype2diabetesmellitusaccompaniedwithCHDwererandomlyallocatedintotwogroups:pioglit5、azonetreatedgroup(,2—28)andnormaltreatedgroup(一32).30healthycontrolswereselectedfromahealthypopulation.Patientsinpio—glitazonetreatedgroupreceivepioglitazonefor8weeks.RBP4,TNF-a,adiponectin,fastingplasmaglucose(FPG),ser—uminsulinleve1,BMI,BP,Plasmatriglyceride(TG)andtota1cholestero1(TC)weremeasured.6、ResultsComparedtohealthycontrolsgroup,RBP4increasedinpatientswithtype2diabetesmellitusaccompaniedwithCHD(P<0.01).Therewasnodifferenceinpioglitazonetreatedgroupandnormaltreatedgroup.TheconcentrationofserumRBP4,TN卜aandseruminsulin1eve1decreased(P<0.01orP<0.05).Theconcentrationofserumadiponectinincreas7、edandIRwasimprovedinpioglitazonetreatedgroup.ConclusionPioglitazonecandecreasetheconcentrationOfserumRBP4andim—proveIRinpatientswithtype2diabetesmellitusaccompaniedwithCHD.[Keywords]RBP4;Type2diabetes
3、管病患者血清RBP4水平,改善IR。【关键词】Ⅱ型糖尿病;冠心病;胰岛素抵抗;视黄醇结合蛋白4;吡格列酮【中图分类号】R587.1;R5414【文献标志码】Adoi:10.3969/].issn.1672-3511.2014.03.020Influenceofpioglitazoneonserumretinolbindingprotein4inpatientswithtype2diabetesmellitusaccompaniedwithCHDZHANGMin,CHENGShu,CHENGPing,etal(DepartmentofElderly;SichuanProvincePeople’H
4、ospital,Chengdu610072)[Abstract]ObjectiveToobservetheeffectofpioglitazoneonserumretinolbindingprotein4(RBP4)inpatientswithtype2diabetesmellitusaccompaniedwithCHDandtentativelyexplorethemechanism.MethodsSixtypatientswithtype2diabetesmellitusaccompaniedwithCHDwererandomlyallocatedintotwogroups:pioglit
5、azonetreatedgroup(,2—28)andnormaltreatedgroup(一32).30healthycontrolswereselectedfromahealthypopulation.Patientsinpio—glitazonetreatedgroupreceivepioglitazonefor8weeks.RBP4,TNF-a,adiponectin,fastingplasmaglucose(FPG),ser—uminsulinleve1,BMI,BP,Plasmatriglyceride(TG)andtota1cholestero1(TC)weremeasured.
6、ResultsComparedtohealthycontrolsgroup,RBP4increasedinpatientswithtype2diabetesmellitusaccompaniedwithCHD(P<0.01).Therewasnodifferenceinpioglitazonetreatedgroupandnormaltreatedgroup.TheconcentrationofserumRBP4,TN卜aandseruminsulin1eve1decreased(P<0.01orP<0.05).Theconcentrationofserumadiponectinincreas
7、edandIRwasimprovedinpioglitazonetreatedgroup.ConclusionPioglitazonecandecreasetheconcentrationOfserumRBP4andim—proveIRinpatientswithtype2diabetesmellitusaccompaniedwithCHD.[Keywords]RBP4;Type2diabetes
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