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时间:2017-12-07
《软组织肉瘤分子靶向治疗临床研究进展》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、国际肿瘤学杂志2010年6月第37卷第6期JIntOneol,June2010,Vo1.37,No.6·46l·versushepatectomyaloneforStageⅢAhepatocelularcarcinoma.JgMur/uraciladministrationaftertranscatheterarterialchemoemboliza—CancerResClinOneol,2009,135(10):1437—1445.tionforadvancedhepatocellularcarcino
2、ma.OncolRep,2008,19[20]PengBG,HeQ,LiJP,eta1.Adjuvanttranscatheterarterialchemo—(5):1355—1361.embolizationimproveseficacyofhepatectomyforpatientswithhepa—[25]BarbareJC,Bouch6O,BormetainF,eta1.Treatmentofadvancedtocellularcarcinomaandpo~alveintumorthrombus.
3、AmJSurg,hepatocellularcarcinomawithlong—actingoctreotide:aphasem2009,198(3):313-318.multicentre,randomised,doubleblindplacebo—controlledstudy.[21]ZhouwP,EC,LiAJ,eta1.Aprospective,randomized,con—EurJCancer,2009,45(10):1788—1797.trolledtrialofpreoperativetr
4、ansarterialchemoembolizationforresect—[26]GalloC,DeMaioE,DiMaioM,eta1.Tamoxfenisnotefectiveinablelargehepatocellularcarcinoma.AnnSurg,2009,249(2):goodprognosispatientswithhepatocellularcarcinoma.BMCCancer,l95—202.2006,6:196—196.[22]MengMB,CuiYL,LuY,eta1.T
5、ranscatheterarterialchemoembo—[27]VersetG,VerslypeC,ReynaertH,eta1.Eficacyofthecombina—lizationincombinationwithradiotherapyforunresectablehepatoeel—tionoflong·actingreleaseoctreotideandtamoxifeninpatientswithlularcarcinoma:asystematicl~viewandmeta-analys
6、is.Radiotheradvancedhepatocellularcarcinoma:arandomisedmultieentrephaseOncol,2009,92(2):184—194.llIstudy.BrJCancer,2007,97(5):582—588.[23]LlovetJM,RicciS,MazzaferroV,eta1.Sorafenibinadvancedhep—atocellularcarcinoma.NEnslJMed,2008,359(4):378—390.(收稿日期:2010
7、一O1—26修回日期:2010-05-04)[24]UedaH,TanakaH,KidaY,eta1.Adjuvantchemotherapywithte一·综述·软组织肉瘤分子靶向治疗临床研究进展孙元珏张剑军综述姚阳审校【摘要】软组织肉瘤(STS)发生中会涉及某些异常分子和基因,使用针对特定分子和基因靶点的药物,选择性杀伤肿瘤细胞,较传统化疗更有效,不良反应更小。但目前绝大多数STS的有效作用靶点尚不明确,试验性靶向治疗疗效多不理想,多靶点药物可能是今后STS靶向治疗的研究方向。【关键词】肿瘤;结缔和软
8、组织;药物疗法;抗肿瘤药ClinicalprospectofresearchonmoleculartargetedtherapyinsofttissuesarcomasSUNYuan-jue,ZHANGJian—jun.DepartmentofMedicalOncology,ShanghaiJiaotongUniversityAffiliatedSixthPeople~Hospi—tal,Shanghai200233,Chin
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