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时间:2020-04-16
《某大豆发酵制品对2型糖尿病大鼠肾脏功能的影响研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第34卷第1期国外医学医学地理分册Vo1.34N0.1。50‘2013年3月F0REIGNMEDICALSCIENCESECT10N0FMEDGEoGRAPHYMar.2O13◇基础医学◇某大豆发酵制品对2型糖尿病大鼠肾脏功能的影响研究杜逸枚,王振林,吉金山(西安交通大学医学院公共卫生系,陕西西安710061)摘要:目的通过观察大豆发酵制品对2型糖尿病大鼠血肌酐、尿素氮变化的影响,探讨大豆发酵制品在预防2型糖尿病肾病中的作用机制。方法SD雌性大鼠高糖高脂喂养8周,出现胰岛素抵抗及高脂血症后空腹腹腔注射链脲佐菌素(sTz30mg/kg·bw),造成2型糖尿病大鼠模型后给予大豆发酵制品干预8
2、周,观察实验大鼠一般情况,测定干预后大鼠血肌酐、尿素氮等含量。结呆大豆发酵制品可降低2型糖尿病大鼠的空腹血糖、饮水量、血肌酐、尿素氮含量,改善高脂血症,肾脏HE染色见结构功能改善明显,进一步的说明其具有对糖尿病大鼠肾脏保健功能。结论大豆发酵制品对2型糖尿病大鼠肾功损伤具有一定保护作用。关键词:2型糖尿病;血肌酐;尿素氮中图分类号:R587.1文献标志码:A文章编号:1001—8883(2013)01—0050—04Thekidneyfunctioneffectsofthefermentedsoybeanontype2diabeticratDUYi—mei,WANGZhen—lin。JIJ
3、in—shan(DepartmentofPublicHealth,MedicalSchoolofXi’anJiaotongUniversity,Xi’an710061,China)ABSTRACT:ObjectivePurposeByobservingtheimpactsofthechangeswhichcomeoutofthetype2diabeticratsserumcretinineaswellasbloodureanitrogenthatresultfromthefermentedsoybeanproducts,theauthoraimstoprobethemechanismof
4、actionoffermentedsoybeanproductsontype2diabeticnephropathyprophylaxi.MethodsFeedingtheSDfemaleratswithhighserumglucoseandserumlipidforeightweeks.WhentheratsshowthesymptomsofIRandhyperlipemia,givethemalimosisintraperiti0nealinjectionofstreptozotocin(STZ30mg/kg·bw),andthataftertheratsturntobethetyp
5、e2diabeticrats,intervenetheprocesswithfermentedsoybeanproductsforeightweeks.Then,observingthegeneralsituationoflaboratorialrats,atthesametime,measuringthecontentsasserumcretinineandureanitrogen.ResultsFermentedsoybeanproductshavetheeffectsofreducingthecontentsoffastingblood—glucose,theamountofdri
6、nkingwater,serumcretinine,aswellasureanitrogen,etc.ontype2diabeticrats.Andtheyalsohavetheinfluencesonimprovinghyperlipemia,andtheHEstainingstructureonkidneyhasbeenimprovedalot,whichfurtherprovesthatthefermentedsoybeanproductshavethehealthfunctionsondiabeticrats.ConclusionFermentedsoybeanproducts,
7、tosomedegree,havetheprotectiveeffectsonrenalinjuryoftype2diabeticrats.KEYWORDS:type2diabeticrat;serumcretinine;ureanitrogen近年来,随着人民生活水平不断提高,饮食结构一直困扰着所有糖尿病患者。糖尿病。肾病是糖尿病的改变,以及糖尿病检测手段的改进,与世界各国一严重并发症之一,已成为慢性肾功能衰竭的第二、第样,我国的
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