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1、第二军医大学学报2004Apr;25(4)·454·AcadJSecMilMedUniv·临床研究·腹膜透析治疗体外循环心脏手术后急性肾功能衰竭赵 枫,徐志云,梅 举,邹良建(第二军医大学长海医院胸心外科,上海200433)[摘要]目的:探讨腹膜透析(PD)对体外循环心脏手术后急性肾功能衰竭(ARF)的治疗效果及其对术后早期血流动力学的影响。方法:回顾88例体外循环心脏手术后ARF行PD治疗患者的临床资料,其中36例术后早期(术后3d)内就行PD治+)-疗,另外52例术后3d后行PD治疗。分析PD前后血
2、尿素氮(BUN)、肌酐(Cr)、钾离子(K、碳酸氢根离子(HCO3)浓度的+变化,对其中36例术后3d内就行PD治疗的患者PD前后的血流动力学进行分析。结果:PD后1d血[K]恢复正常,1~4-d内血[HCO3]恢复正常,4~6d内BUN下降49.2%,Cr下降42.6%(P<0.05),Cr在3~16d时恢复到术前水平,PD治疗后3~39d内肾功能恢复。36例术后3d内就行透析的患者,平均动脉压(MAP)和心脏指数(CI)在PD后有所上升,但与PD前相比无显著差异。结论:PD对体外循环心脏手术后ARF
3、有较好的治疗效果,对血流动力学无明显影响,是一种安全、有效的治疗措施;对心脏术后合并ARF者,应及早进行PD治疗,并且需强调PD的持续性与充分性,以提高其疗效。[关键词]体外循环;心脏外科手术;肾功能衰竭,急性;腹膜透析[中图分类号]R654.206;R652.502[文献标识码]B[文章编号]02582879X(2004)0420454202Peritonealdialysisforacuterenalfailurefollowingcardiacsurgerywithcardiopulmonaryb
4、ypassZHAOFeng,XUZhi2Yun,MEIJu,ZOULiang2Jian(DepartmentofCardiothoracicSurgery,ChanghaiHospital,SecondMili2taryMedicalUniversity,Shanghai200433,China)[ABSTRACT]Objective:Toevaluatethetherapeuticeffectivenessofperitonealdialysis(PD)foracuterenalfailure(ARF
5、)followingcardiacsurgerywithcardiopulmonarybypassanditseffectonhemodynamics.Methods:Retrospectivedatafrom88patientswithARFfollowingcardiacsurgeryundergoingPDwereanalyzed.Results:Therenalfunctionofthepatientsrecov2+-eredwithin3to39dofPD,[K]declinedtonorma
6、llevelwithin1d,[HCO3]declinedtonormallevelwithin124d,andBUNandCrdeclinedby49.2%and42.6%respectivelywithin426dofPD(P<0.05).Meanarterypressure(MAP)andcar2diacindex(CI)ofthepatientsundergoingPDearlypost2operation(within3d)didnotchangesignificantlyduringanda
7、fterPD.Conclusion:PDhasagoodtherapeuticeffectivenessforARFfollowingcardiacsurgerywithcardiopulmonarybypasswithoutobviouseffectsonhemodynamics.Toimproveitstherapeuticeffectiveness,PDshouldbeperformedassoonasARFisdiagnosedandshouldbelastedforenoughtime.[KE
8、YWORDS]cardiopulmonarybypass;cardiacsurgicalprocedures;kidneyfailure,acute;peritonealdialysis[AcadJSecMilMedUniv,2004,25(4):4542455]X 急性肾功能衰竭(ARF)是体外循环心脏手术后的严重58例,MVR+房颤迷宫术(Maze)2例,MVR+冠状动脉旁并发症,是术后死亡的独立危险因素,及时有效地治疗ARF路移植术4