冠状病毒Coronavirusl论文-2006 Generation of Coronavirus-based multigene RNA vectors.pdf

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1、CancerPrevention2006PosterAbstracts-Oncogenetics45roleofgeneticfactorisaperspectivedirectionofoncogy-butpropagationdeficientvectors.Animportantconsiderationnecology.Theclinical-genealogicalanalysisofthousandsofforviralvaccinevectorsisthepotentialforefficientdeliverygeneal

2、ogiesofpatientswithcanceroffemalereproductiveor-oftheirgeneticmaterialtospecifictargetcells.Targetingofgans,allowedH.Linchetaltounifytheclinical-genealogicalviralvaccinevectorstodendriticcells(DCs)ishighlydesir-criteriawhichallowtodistinguishbetweeninheritedandspo-ableino

3、rdertooptimisevaccineefficacy.Themousehepatitisradictumors.Thestudygoalwasestablishmentoffeaturesvirus(MHV)andthehumancoronavirus(HcoV)229Ehaveandpatternsofdistributionoftumorsinfamiliesofpatientstheirreceptors(CEACAM-1andhAPNorCD13,respectively)withovarianandendometrialc

4、ancer.Theclinical-genealogicalexpressedonDCsandmacrophages.ThisindicatesthatMHVanalysisof520patientswithovariancancerand482patientsandHCoV229EbasedvectorscouldbeusedtodelivergeneticwithendometrialcancerinChernivtsiregionwasconducted.cargoefficientlytoDCsviareceptor-mediat

5、edtransduction.TheanalysisrevealedthatthemostcommonmalignanciesinSinceMHVisabletoinfectDCs,recombinantMHVvectorsfamiliesofthesepatientsweretumorsoffemalereproductiveinthecontextofamurinemodelcanserveasaparadigmfororgans(ovarian,endometrialandbreastcancer),gut(stom-thedeve

6、lopmentandevaluationofcoronavirusvaccinevectorsach,colon),lungs,prostateetc.Among520genealogiesofsuitableforinvitroandinvivotransductionofhumanDCs.Thepatientswithovariancancerand482genealogiesofpatientsanticipatedresultsinthemurineanimalmodelwillguidethewithendometrialcan

7、cerweselected103genealogiesinwhichdevelopmentofcoronavirus-basedvaccinesingeneralandwillmalignanttumorsoffemalereproductivesphereweretwicepavethewayforthegenerationofHCoV229E-basedvaccinesmorecommon,whichisaclinical-genealogicalcriterionofinhumans.familycanceroffemalerepr

8、oductivesphere.Weanalyzedthespectrumoffamilyaggregationofcancerofdifferentanatomiclocalizationsi