冠状病毒Coronavirusl论文-2004 Biosafety Risk Assessment of the Severe Acute Respiratory Syndrome (SARS) Coronavirus and Containment Measures for.pdf

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1、ArticleAppliedBiosafety,9(3)pp.128-142©ABSA2004BiosafetyRiskAssessmentoftheSevereAcuteRespiratorySyndrome(SARS)CoronavirusandContainmentMeasuresfortheDiagnosticandResearchLaboratoriesP.Herman1,Y.Verlinden1,D.Breyer1,E.VanCleemput1,B.Brochier1,M.Sneyers1,R.Snacken1,P.Hermans2,P.K

2、erkhofs3,C.Liesnard4,B.Rombaut5,M.VanRanst6,G.vanderGroen7,P.Goubau8,andW.Moens11ScientificInstituteofPublicHealth,Brussels,Belgium,2UniversitéLibredeBruxelles—CHUStPierre,Brussels,Belgium,3CODA-CERVA-VAR,Brussels,Belgium,4UniversitéLibredeBruxelles—HôpitalErasme,Brussels,Belgiu

3、m,5VrijUniversiteitBrussel,Brussels,Belgium,6RegaInstitute,NationalSARSReferenceLaboratory,Leuven,Belgium,7InstituutvoorTropischeGeneeskunde,Antwerpen,Belgium,8UniversitéCatholiquedeLouvain,BelgiumKeywordsclassifiedasaRiskGroup3agent.Inrelationtothereportedbiosafetyassessment,th

4、eSARS-CoVshouldSARS,coronavirus,riskAssessment,biosafety,behandledinappropriatebiosafetycontainmentlevelsdiagnosisandresearchlaboratories,containedusetoavoidlaboratory-acquiredinfectionsandspreadofthediseaseinthehumanpopulationandtheenviron-Abstractment.Therefore,diagnosticactiv

5、itieswithinactivatedclinicalspecimensassociatedwithSARScasesandwithAttheendof2002,anoutbreakofanewviralspecimensoriginatingincountrieswhereSARSisdocu-respiratoryillness,calledSARS(SevereAcuteRespira-mentedbutnotassociatedwithSARScasesshouldbetorySyndromevirus),occurredinChina.Th

6、ediseaseperformedunderBiosafetyLevel2(BSL-2)conditions.spreadoverAsia,NorthAmerica,Europe,andAfrica.DiagnosticactivitiesinvolvingnoninactivatedclinicalInresponsetotheSARSoutbreak,theWorldHealthspecimensassociatedwithSARSshouldbecarriedoutOrganization(WHO)coordinatedaninternation

7、alunderBSL-2containmentwithBSL-3safetyequip-collaborationthatincludedclinical,epidemiologic,andmentandworkpractices.CultureofSARS-CoVandlaboratoryinvestigations,andinitiatedeffortstocon-allresearchactivitiesinvolvingSARS-CoVrequireatrolthespreadofSARS.Asinothercountries,Bel-BSL-

8、3containment.giumhasbeendecidedtoestablishbiosa