奥拉西坦联合盐酸法舒地尔治疗血管性痴呆的疗效.pdf

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1、4·实用临床医学20l4年第15卷第8期PracticalnicalMedicine，2014，Vol15，No8·奥拉西坦联合盐酸法舒地尔治疗血管性痴呆的疗效杨平(江西省人民医院干部病房神经内科，南昌330006)摘要：目的探讨奥拉西坦联合盐酸法舒地尔治疗血管性痴呆(VD)的临床疗效与安全性。方法将90例VD患者按髓机数字表法分为3组：A组3O例采用奥拉西坦联合盐酸法舒地尔治疗。B组30例采用奥拉西坦治疗，C组30例采用盐酸法舒地尔治疗．14d为1疗程治疗2个疗程后比较3组治疗前后MoCA评分变化及不良反应发生率。结果与治疗前比较，3组治疗后MoCA评

2、分均显著升高(P<0．05)；A组治疗后MoCA评分改善程度显著优于B、C组(P

3、ridef0rVascularDementiaYANGPing(DepartmentofNeurology,CardreWardofJiangxiProvincePeople’sHospital,Nanchang330006，China)ABSTRACT：ObjectiveToinvestigatetheclinicalefficacyandsafetyofoxiracetamcombinedwithfasudilhydrochlorideinthetreatmentofvasculardementia(VD)．MethodsNinetypatients

4、withVDwererandomlydividedintothreegroups：groupA(combinedtreatmentwjthoxiracetamandfasudilhydroc—hloride)，groupB(treatmentwithoxiracetamalone)，andgroupC(treatmentwithfasudilhydrochloridealone)，with30patientsineachgroup．Acourseoftreatmentwas14days．Aftertwocoursesoftreatment，thechan

5、geinMoCAscoresandtheincidenceofadversereactionswerecomparedamongthethreegroups．ResultsTheMoCAscoressignificantlyincreasedaftertreatmentinallthethreegroups(尸<0．05)．ComparedwithgroupBorC，MoCAscoresweresignificantlyimprovedaftertreatmentingroupAf尸<0．05)．Therewerenosignificantdiffere

6、ncesintheincidenceofadversereactionsamongthethreegroups．>0．05)．ConclusionThecombinedtreatmentwithoxiracetamandfasudilhydrochloridecanimprovetheclinicalsymptomsofVDanddelaytheprogressionofdementiathroughselectivelyactivating，protectingandpromotingtherestoreofdamagednervecells，amel

7、ioratingbraincirculation，increasingcerebralbloodflow，andinhibitinginflammatoryresponse．KEYWORDS：oxiracetaminjection；fasudilhydrochloride；vasculardementia；clinicalefficacy；adversereactions血管性痴呆(vasculardementia，VD)是指各种原和干预将十分必要。笔者采用对比研究方法探讨奥因引起的脑血管供血障碍导致的认知功能障碍临拉西坦联合盐酸法舒地尔治疗VD的临床疗

8、效与安床综合征，是老年期痴呆常见病因，严重危害老年全性，报告如下。人身体健康和生