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1、临床医学论文•黄罠对血液透析患者氧化应激的影响作者:曲晓璐,戴芹,漆映辉,唐咏华,徐达华,吴屮华,王晓【摘要】口的:了解维持性血液透析(mainlenancehemodialysis,MHD)患者的氧化应激及微炎症状态,观察黄英对其的影响。方法:选取60例MHD患者随机分为2组,在透析过程中给予(治疗组)或不予(对照组)黄茂注射液治疗12周,另选取年龄和性别匹配的健康成年志愿者10例为健康人组。荧光分光光度法测定血浆晚期糖基化终末产物(advancedglycationendproducts,AGEs)、晚期蛋白质氧化产物(advancedoxidat
2、ionproteinproduct,AOPP)、脂氧化终末产物丙二醛(malondialdehyde,MDA)及维生素E(vitaminE,VitE)含量;酶联免疫吸附法(enzymelinkedimmunosorbentassay,ELISA)测定血浆C反应蛋白(Creactiveprotein,CRP)含量。结果:与健康人比较,MHD患者血浆AGEs、AOPP、MDA和CRP含量显着升高(P<0.01),VitE含量显着降低(P<0・01);黄罠注射液治疗12周后,MHD患者血浆AGEs、AOPP、MDA和CRP含量明显下降(P<0・05,P<0.
3、01),VitE浓度无变化(P>0.05)o结论:MHD患者存在明显的氧化应激及微炎症状态;黄茂注射液可在一定程度上降低其氧化产物的蓄积,减轻微炎症状态,但减少抗氧化剂VitE丢失的作用不明显【关键词】黄英;血液透析;氧化性应激Methods:SixtyMHDpatientswereincludedandrandomizedintotreatmentgroupandcontrolgroup,withanother10healthyvolunteersasnormalcontro1.Thepatientsinthetreatmentgroupweretr
4、eatedwithAstragalousInjectionandthepatientsinthecontrolgroupweretreatedwithnormalsalinefor12weeks.Aspectrophotometricmethodwasusedforthemeasurementofplasmaconcentrationsofoxidativeparametersincludingadvancedglycationendproducts(AGEs),advancedoxidationproteinproduct(AOPP),malondi
5、aldehyde(MDA)andvitaminE(VitE).ThecontentofCreactiveprotein(CRP)wasevaluatedbyenzyme1inkedimmunosorbentassay.Results:Comparedwiththenormalcontrolgroup,theplasmalevelsofAGEs,AOPP,MDAandCRPweresignificantlyincreased,whileplasmalevelofVitEwassignificantlydecreasedinMHDpatients(P<0.
6、01)・AfterAstragalousTnjectiontreatment,theplasmalevelsofAGEs,AOPP,MDAandCRPweredecreasedascomparedwiththecontrolgroup(PcO.Ol),whiletherewasnosignificantdifferenceinplasmaVitElevelbetweenthetreatmentgroupandcontrolgroup.Conclusion:ThereexistoxidativestressandmicroinflammationinMH
7、Dpatients・AstragalousTnjectioncanamelioratetheaccumulationofoxidativcproductsandmicroinflammatorystatus,butithasnosignificanteffectonplasmaVitEleve1.Keywords:Astragalousmembranaceus;hemodialysis;oxidativestress维持性血液透析(maintenancehemodialysis,MHD)患者的年死广率达9%~25%,其致死原因主耍是心血管系统疾病、感染
8、及各种远期并发症。近10年来的研究揭示,这些并发症与机体长期处于高氧化状态密切相关,氧化应激是