痤疮丙酸杆菌

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1、Propionibacteriumacnes-ReactiveTHelper-1CellsintheSkinofPatientswithAcneVulgaris存在于寻常痤疮患者皮肤中的痤疮丙酸杆菌T助细胞—1TotheEditor:Acnevulgarisisthecommonestskindisordertoaffecthumans,characterizedbybothnoninfammatory(comedones)andinflammatorylesions(papules,pustules,andnodulocysticlesio

2、ns).Itisadiseaseofthepilosebaceousfolliclewithcomedonesresultingfromthehypercornificationofthekeratinocytesoftheductwallandusuallyprecedinginflammatorylesions(Cunliffeetal,2000).寻常痤疮是最普通的能影响人体健康的皮肤紊乱疾病，既有非发炎性（如粉刺）又有发炎性（如丘疹、脓包、结囊肿损害）损害特点，这是一种毛皮脂腺囊疾病，输送管壁的角蛋白超角质化或上面提到的发炎性损害导致了

3、粉刺的形成（Cunliffeetal，2000）OfparticularinterestinthepathophysiologyofinflammatoryacneistheroleofthenormalskincommensalbacteriumPropionibacteriumacnes.Althoughnotarequirementforcomedogenesis,anumberofobservationshavesuggestedthatP.acnesisimplicatedinthepathogenesisofinflammatory

4、acne.至于病理生理学上的发炎性损害，正常皮肤共生的细菌—丙酸杆菌粉刺起着特殊作用，尽管并不需要分生孢子，但是通过观察发现丙酸杆菌粉刺和感染性损害的发病机制有关系ThedensityofP.acnesincreasesmarkedlyduringpubertycoincidingwiththeonsetofthedisease(Leydenetal,1975).P.acnesisrarelyfoundinanimalskinandacneisnotseeninanimals(Websteretal,1981;Kearneyetal,1982)

5、.TreatmentsthatreduceP.acnesnumbersleadtoclinicalimprovementofacne(Thiboutot,1997)and,finally,theemergenceofantibiotic-resistantP.acnesstrainsarelinkedtothefailureofantibiotictreatment(Eadyetal,1989).该病始于青春期，此间丙酸杆菌分析的数量显著增加，很少在动物皮肤发现丙酸杆菌痤疮，在动物体内也无发现痤疮，试图通过临床试验减少痤疮丙酸杆菌数量，抗生素疗

6、法因为产生了抵抗抗生素的菌株而失败（Eadyetal，1989），TheimmunostimulatoryactivityofP.acnesandresultingprototypicThelper1immuneresponsehasbeenwidelystudiedinanimalmodels(Matsuietal,1997;Okazakietal,2001);however,thespecificityandcytokineprofilesoflesionalTcellsfromskinofacnepatientshavenotbeenin

7、vestigatedpreviously已经利用动物模型对痤疮丙酸杆菌引起的免疫活动和由原T助细胞引发的免疫应答进行了广泛的研究，然而还没有对痤疮病人皮肤受损害的T细胞原型及细胞因子原型的研究，HerewedescribethegenerationofTcelllines(TCL)frominflamedacnelesions,and,theirproliferativeandcytokineresponsestoP.acnesantigens.ApprovalwasgrantedforthisresearchprojectbytheHamme

8、r-smithQueenCharlotte’s&ChelseaandActinHospitalsResearchEthicsCommittee.Ful