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1、Propionibacteriumacnes-ReactiveTHelper-1CellsintheSkinofPatientswithAcneVulgaris存在于寻常痤疮患者皮肤中的痤疮丙酸杆菌T助细胞—1TotheEditor:Acnevulgarisisthecommonestskindisordertoaffecthumans,characterizedbybothnoninfammatory(comedones)andinflammatorylesions(papules,pustules,andnodulocysticlesio
2、ns).Itisadiseaseofthepilosebaceousfolliclewithcomedonesresultingfromthehypercornificationofthekeratinocytesoftheductwallandusuallyprecedinginflammatorylesions(Cunliffeetal,2000).寻常痤疮是最普通的能影响人体健康的皮肤紊乱疾病,既有非发炎性(如粉刺)又有发炎性(如丘疹、脓包、结囊肿损害)损害特点,这是一种毛皮脂腺囊疾病,输送管壁的角蛋白超角质化或上面提到的发炎性损害导致了
3、粉刺的形成(Cunliffeetal,2000)OfparticularinterestinthepathophysiologyofinflammatoryacneistheroleofthenormalskincommensalbacteriumPropionibacteriumacnes.Althoughnotarequirementforcomedogenesis,anumberofobservationshavesuggestedthatP.acnesisimplicatedinthepathogenesisofinflammatory
4、acne.至于病理生理学上的发炎性损害,正常皮肤共生的细菌—丙酸杆菌粉刺起着特殊作用,尽管并不需要分生孢子,但是通过观察发现丙酸杆菌粉刺和感染性损害的发病机制有关系ThedensityofP.acnesincreasesmarkedlyduringpubertycoincidingwiththeonsetofthedisease(Leydenetal,1975).P.acnesisrarelyfoundinanimalskinandacneisnotseeninanimals(Websteretal,1981;Kearneyetal,1982)
5、.TreatmentsthatreduceP.acnesnumbersleadtoclinicalimprovementofacne(Thiboutot,1997)and,finally,theemergenceofantibiotic-resistantP.acnesstrainsarelinkedtothefailureofantibiotictreatment(Eadyetal,1989).该病始于青春期,此间丙酸杆菌分析的数量显著增加,很少在动物皮肤发现丙酸杆菌痤疮,在动物体内也无发现痤疮,试图通过临床试验减少痤疮丙酸杆菌数量,抗生素疗
6、法因为产生了抵抗抗生素的菌株而失败(Eadyetal,1989),TheimmunostimulatoryactivityofP.acnesandresultingprototypicThelper1immuneresponsehasbeenwidelystudiedinanimalmodels(Matsuietal,1997;Okazakietal,2001);however,thespecificityandcytokineprofilesoflesionalTcellsfromskinofacnepatientshavenotbeenin
7、vestigatedpreviously已经利用动物模型对痤疮丙酸杆菌引起的免疫活动和由原T助细胞引发的免疫应答进行了广泛的研究,然而还没有对痤疮病人皮肤受损害的T细胞原型及细胞因子原型的研究,HerewedescribethegenerationofTcelllines(TCL)frominflamedacnelesions,and,theirproliferativeandcytokineresponsestoP.acnesantigens.ApprovalwasgrantedforthisresearchprojectbytheHamme
8、r-smithQueenCharlotte’s&ChelseaandActinHospitalsResearchEthicsCommittee.Ful