肾移植患者血清胱抑素C及肌酐清除率相关性探究

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1、肾移植患者血清胱抑素C及肌酹清除率相关性探究作者：粟宏伟卢一平何毅杨海帆姜睿陈同良【摘要】目的探讨肾移植患者血清胱抑素C(SCysC)浓度作为移植肾功能测定指标的可行性和临床应用价值。方法采用颗粒增强透射免疫比浊法(PETIA)分别检测39例初次肾移植患者在术前、术后1周和4周的SCysC水平，并与血清肌酹(Scr)、内生肌酹清除率(Ccr)进行比较分析。结果肾移植术前与术后，患者的SCysC与Scr、Ccr都具有很好的相关性。SCysC与Scr呈正相关(术前「=0.849;术后r=0.940);与Ccr呈负相关(术前r二0.857;术后—0.876);按Cc

2、r分组的统计分析结果显示：不同肾功能水平的SCysC与Ccr的相关性均较Scr与Ccr的相关性相似或更佳。当50

3、altransplantationABSTRACT:ObjectiveToevaluatethefeasibilityandclinicalvalueofserumcystatinC(SCysC)inassessingrenalfunctionofpatientswithrenaltransplantation.MethodsThirtyninepatientswithrenaltransplantationwererecruitedinthestudy.SCysCandserumcreatinine(Scr)weredeterminedbeforesurge

4、ry,1weekand4weeksaftersurgery,respective!y.SCysCwasdeterminedbyparticleenhaneedturbidimetricimmunoassay(PETIA).ThecorrelationsamongSCysC,ScrandCcrwerecomparedbyusingpearsoncorrelationanalysis・ResultsEitherduringthepreoperativeorpostoperativeperiod,SCysCshowsasignificantcorrelationwi

5、thScrandCcr.SCysCandScrispositivelycorrelated(r=0.849preoperatively,andr=0.940postoperatively).SCysCandCcrisnegativelycorrelated(r=-0.857preoperatively,andr=-0.876postoperatively).SCysCindifferentCcrlevelshowssimilarorclosercorrelationwithCcrthanScrdoes・AtaCcrlevelof50-80mL/(min-1.7

6、3m2),thecorrelationbetweenSCysCandCcr(r=-0.778)issignificantlybetter(P<0.05)thanthatbetweenScrandCcr(r=-0.553).ConclusionBothScrandCcrcorrelatewellwithSCysCinpatientswithrenaltransplantation.SCysCcanbeusedasanidealmarkerofrenalfunctionforclinicalmonitoringintheadultpatients.KEYWO

7、RDS:serumcystatinC;renaltransplantation;serumcreatinine;creatinineclearanee近年来的研究发现，血清胱抑素C(serumcystatinC,SCysC)是一种较理想的测定肾脏功能的内源性标记物。SCysC又名半胱氨酸蛋白酶抑制蛋白C，是一种低分子非糖基化的碱性蛋白，在所有有核细胞内表达，并且以恒定的速度产生；能被肾小球自由滤过，不被肾小管分泌。此外,SCysC不受炎症、胆红素、溶血、甘油三脂的影响，并与性别、年龄、肌肉量无关口］。国内目前已有较多在健康者或在非肾移植患者中SCysC的研究，

8、但还缺乏在肾移植患者中的研究，本研究探