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1、益气滋阴、清热活血法治疗狼疮性肾炎临床研究【摘要】丨
2、的观察以屮医益气滋阴、清热活血原则组方的滋阴清斑汤配合西药治疗狼疮性肾炎(LN)阴虚内热型的临床疗效，以及对患者口身抗体、补体的影响。方法将阴虚内热型LN患者60例随机分为试验组40例和対照组20例。2组均给予控制感染，维持水、电解质、酸碱平衡，控制并发症，应用激素等治疗,试验纽•在此基础上配合服用滋阴淸斑汤，用药6个月。观察2组治疗前肩临床症状及实验室检查的变化情况。结果试验组总有效率为87.5%(35/40),对照组为70.0%(14/20),2组比较差异有统计V意义(Pv0.05);试验组在改善患者临床症状积
3、分，升高红细胞、•血红蛋口、补体C3,及降低血肌酊•、尿蛋白等方而效果优于对照组(PvO.05或PvO.Ol),且对改善某些临床症状效果佼好。结论中西医结合治疗在改善LN患者临床症状和实验室指标、提高整体疗效方血效果更好。【关键词】益气滋阴;清热活血;滋阴清斑汤;狼疮性肾炎;阴虚内热型;中西医结合疗法Abstract：ObjectiveToinvestigatetheclinicaleffectonlupusnephritis(LN)patientswithyindeficiencyandinnerheatsyndrome,andtheinfluenceonautoa
4、ntibodiesandcomplementstreatedbyZiyinQingbaiisoup,whichwasformedwiththeprincipleofqi-enrichingandyin-reinforcing,blood-activatingandheat-clearingtherapy,combinedwithwesternmedicine.MethodsSixtyLNpatientswithyindeficiencyandinnerheatsyndromewererandomlydividedinto2groups,40casesinthetria
5、lgroupand20casesinthecontrolgroup.Bothgroupsweretreatedwithcontrollinginfecting,maintainingbalanceofwater,electrolyteandacid-base,controllingcomplicationandimmunity-restrainingdrugs,suchasadrenocorticalhormones.ThetrialgroupwastreatedwithZiyinQingbansoupadditionallyfor6months.Theclinica
6、lsymptomsandlaboratoryindicatorsofthetwogroupsbeforeandaftertreatmentwereobserved.ResultsThetotaleffectiverateofthetrialgroupwas87.5%(35/40),whilethatofthecontrolgroupwas70.0%(14/20),therewasasignificantdifference(P<0.05).Thetrialgroupwassuperiortothecontrolgroupinimprovingtheclinicalsy
7、mptomsscores,raisingRBC,Hb,C3,andloweringSCrandproteinuria,etc(P<().()5orP<().()1).ConclusionTheintegratedtreatmentofTCMandwesternmedicinehadgoodeffectonsymptomsandlaboratoryindexesofLNpatients,thusmayimprovethewholecurativeeffect.Keywords:qi-enrichingandyin-reinforcing;bloodactivatinga
8、ndheat-clearing;ZiyinQingbansoup;lupusnephritis;yindeficiencyandinnerheatsyndronie;integratedtreatmentofTCMandwesternmedicine狼疮性丫予炎(lupusnephritis,LN)是系统性红斑狼疮(systemiclupuserythematosus,SLE)导致的肾损害。LN是继发性肾脏病中最常见的一•种。SLE是一种累及多种自身抗体的自体免疫性疾病,肾脏是主要受累器官，肾损害在SLE全过程中占重要地位，也是患者死亡的主要原因之一
