(HST)Calibrating the BOLD signal during a motor task using an extended fusion model

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1、NeuroImage61(2012)1268–1276ContentslistsavailableatSciVerseScienceDirectNeuroImagejournalhomepage:www.elsevier.com/locate/ynimgCalibratingtheBOLDsignalduringamotortaskusinganextendedfusionmodelincorporatingDOT,BOLDandASLdataa,⁎,TheodoreJ.Huppertba,ca,cMeryemA.Yücel,DavidA.Boas,LouisGagno

2、naAthinoulaA.MartinosCenterforBiomedicalImaging,DepartmentofRadiology,MassachusettsGeneralHospital,HarvardMedicalSchool,Charlestown,MA,USAbDepartmentofRadiologyandBioengineering,UniversityofPittsburg,Pittsburg,PA,USAcHarvard-MITDivisionofHealthSciencesandTechnology,Cambridge,MA,USAarticl

3、einfoabstractArticlehistory:MultimodalimagingimprovestheaccuracyofthelocalizationandthequantificationofbrainactivationwhenAccepted16April2012measuringdifferentmanifestationsofthehemodynamicresponseassociatedwithcerebralactivity.InthisAvailableonline23April2012study,weincorporatedcerebralb

4、loodflow(CBF)changesmeasuredwitharterialspinlabeling(ASL),DiffuseOpticalTomography(DOT)andbloodoxygenlevel-dependent(BOLD)recordingstoreconstructchangesinKeywords:oxy-(ΔHbO2)anddeoxyhemoglobin(ΔHbR).UsingtheGrubbrelationbetweenrelativechangesinCBFandfNIRScerebralbloodvolume(CBV),weincorpo

5、ratedtheASLmeasurementasapriortothetotalhemoglobincon-fMRIASLcentrationchange(ΔHbT).WeappliedthisASLfusionmodeltobothsyntheticdataandexperimentalmul-CMROtimodalrecordingsduringa2-sfinger-tappingtask.Ourresultsshowthatthenewapproachisvery2BOLDcalibrationpowerfulinestimatingΔHbO2andΔHbRwith

6、highspatialandquantitativeaccuracy.Moreover,ourMultimodalimagingapproachallowsthecomputationofbaselinetotalhemoglobinconcentration(HbT0)aswellasoftheBOLDcalibrationfactorMonasinglesubjectbasis.WeobtainedanaverageHbT0of71μM,anaverageMvalueof0.18andanaverageincreaseof13%incerebralmetabolic

7、rateofoxygen(CMRO2),allofwhichareinagreementwithvaluespreviouslyreportedintheliterature.Ourmethodyieldsanindependentmea-surementofM,whichprovidesanalternativemeasurementtovalidatethehypercapniccalibrationoftheBOLDsignal.©2012ElsevierInc.Allrightsreserved.Introductioninani