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ID:39840082
大小:117.20 KB
页数:4页
时间:2019-07-12
《Increased Prevalence of Chronic Rhinosinusitis in Carriers of a Cystic Fibrosis Mutation》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、ORIGINALARTICLEIncreasedPrevalenceofChronicRhinosinusitisinCarriersofaCysticFibrosisMutationXinJingWang,MD,PhD;JeanKim,MD,PhD;RitaMcWilliams,PhD,MPH;GarryR.Cutting,MDObjective:Toexplorewhetherthereisanincreasedwhoreturnedacompletedquestionnairehadself-prevalenceofchronicrhinosinusitis(CRS)in
2、knowncys-reportedCRS.Twenty-threeCFcarriers(14withand9ticfibrosis(CF)carriers.Self-reportedCRSaffects13%withoutCRSbasedonself-reportinginthequestion-to14%oftheUSpopulationandclustersinfamilies,whichnaire)wereclinicallyevaluated.Sevenwerediagnosedsuggeststhatgeneticfactorsmayplayanetiologicro
3、le.ashavingCRS(all7withself-reportedCRS),whilean-Cysticfibrosisisaninheritedrecessivedisorderthatin-other6hadallergicrhinitisorrecurrentacuterhinosi-variablyaffectsthesinuses.ThefrequencyofCFmuta-nusitis(all6withself-reportedCRS),and10hadnoevi-tionshasbeenreportedtobehigherinpatientswithCRSd
4、enceofactivesinusdisease(1withself-reportedCRS).thaninunaffectedcontrols.Thesensitivity(100%)andspecificity(56%)oftheques-tionnaireforphysician-diagnosedCRSwassimilartothatPatients:ObligateCFcarriers(parentsofpatientswithofothersurveyinstrumentsusedtoestimatethepreva-CF)wererecruitedfromtheJ
5、ohnsHopkinsCFclinic.lenceofself-reportedCRSinthegeneralpopulation.ThepresenceofsignsandsymptomsofCRSwasas-sessedbyasinusdiseasequestionnaire.AsubgroupofConclusion:CarriersofasingleCFmutationhaveaparticipantswasevaluatedbyaphysicianexperiencedinhigherprevalenceofCRSthanthegeneralpopulation.th
6、ediagnosisofCRS.Results:Fifty-three(36%)of147obligateCFcarriersArchOtolaryngolHeadNeckSurg.2005;131:237-240HRONICRHINOSINUSITISneticlinkagestudieshavenotbeenre-(CRS)isthemostpreva-portedforCRS,ourgroupandothershavelentchronicconditioninshownthatthefrequencyofcysticfibrosistheUnitedStates.The
7、(CF)mutationsinpatientswithCRSisChigherthanindisease-freecontrols.9-11AprevalenceofCRShasbeenestimatedat141.3per1000personsroleforCFmutationsinthedevelopment(14%)inoneNationalHealthInterviewofCRSinthegeneralpopulationisbasedSurvey1and125.5per1000pe
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