医学英语医英immunesystem

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1、Lymphatic/ImmunesystemGangXINDepartmentofMicrobiologyandImmunologygxin@stu.edu.cn18923912518Smallpoxdeathsofanestimated 300to500million peopleEdwardJenner1749-1823"Father"ofImmunologyvaccinationIn1796http://en.wikipedia.org/wiki/Edward_JennerL.vaccinus,relatingtoacow,vacca1802caricatureofJenne

2、rvaccinatingpatientswhofeareditwouldmakethemsproutcowlikeappendages.1979.10.26TheannouncementbytheWHOthatsmallpoxwasthefirstdiseasethathadbeeneradicatedworldwidebyaprogramofvaccinationLouisPasteur1822-1895The“Father”oftheModernMicrobiologyVaccines:1880,chickencholera1881,anthrax1885,rabiescons

3、ciouslyimmunesystemWhatisit?Whereisit?Howdoesitwork?Whatisimmunity?immunityImmunesystemImmuneresponseImmunologyImmunologistImmunodeficiencyImmunocompromisedIMMUNITY←←IMMUNIS(EXEMPT)Latin:ProtectionfromlegalprosecutionNow,inmedicalterms:freeofdisease.BubbleboyDavidVetter(1971~1984)http://www.pb

4、s.org/wgbh/amex/bubble/peopleevents/p_vetter.htmlseverecombinedimmunodeficiency(SCID)InfectionLymphomacongenitalimmunodeficiencypresentatbirthHIVandAIDSHIV-humanimmunodeficiencyvirusAIDS-acquiredimmunedeficiencysyndromeARC:AIDS-relatedcomplexARCis"AprodromalphaseofeffectsphaseofinfectionwithHI

5、V.Symptomscanincluderecurringfever,unexplainedweightloss,swollenlymphglands,diarrhea,orfungalinfectionofthemouth.CandidainfectionsOpportunityInfectionandCancerFungal,bacterial,viralandprotozoalinfectionThemostfrequentopportunistictumour,Kaposi'ssarcoma,isobservedin20%ofpatientswithAIDS.Maligna

6、ntlymphomasarealsofrequentlyseeninAIDSpatients.Kaposi’ssarcomaKaposi’ssarcomaKaposi'ssarcomaontheskinofanAIDSpatient.lymphomaFunctionsofImmunesystemimmunedefencedefenseagaistinfectiousdiseasesimmunesurveillancekillcancercellsimmunehomeostasismaintaininternalequilibriumWhereisimmunesystem?Organ

7、sCellsMoleculesImmuneorgansCentralimmuneorgansThesiteofgeneration,differentiationandmaturationoflymphocytesincludingbonemarrowthymusBonemarrowHematopoieticstemcellMyeloidprogenitorLymphoidprogenitorFunctions:Thesiteofgenerationofallcirc