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时间:2019-06-17
《17例腮腺肌上皮癌的诊治分析》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·392·中华肿瘤杂志2015年5月第37卷第5期ChinJOncol,May2015,Vol.37,No.5·临床应用·17例腮腺肌上皮癌的诊治分析刘绍严倪松朱一鸣王健【摘要】目的分析17例腮腺肌上皮癌的的临床特点、诊治情况及预后。方法对1999年至2013年收治的17例腮腺肌上皮癌患者进行回顾性分析。17例患者中,9例行单纯手术治疗,5例行术后放疗,2例行术前放疗,1例行化疗。应用Kaplan-Meier法计算患者的生存率。结果17例患者中,术后复发11例,复发率为647.%。在复发的11例患者中,有5例(45.5%)患者在初次手术1年内复发。随访期间,死亡6例,其
2、中2例死于远处转移,4例死于局部复发。17例患者的1、2和5年生存率分别为94.1%、74.2%和64.9%,1、2和5年无复发生存率分别为70.6%、48.1%和40.1%。结论根治性手术切除是腮腺肌上皮癌的主要治疗方式。对于病变广泛或姑息手术的腮腺肌上皮癌患者,可以考虑辅助放化疗,但疗效有待进一步研究证实。【主题词】腮腺肿瘤;外科手术;放射疗法;药物疗法;肿瘤复发,局部;肿瘤转移;预后Analysisofthediagnosisandtreatmentofmyoepithelialcarcinomaoftheparotidgland:reportof17casesL
3、iuShaoyan,NiSong,ZhuYiming,WangJian.DepartmentofHeadandNeckSurgery,CancerHospital,ChineseAcademyofMedicalSciences&PekingUnionMedicalCollege,Beijing100021,ChinaCorrespondingauthor:LiuShaoyan,Email:saoyanliu@163.com【Abstract】ObjectiveMyoepithelialcarcinoma(MC)isararemalignantneoplasmofthes
4、alivarygland.Theaimofthisstudywastoanalyzethediagnosis,treatmentandprognosisofMCoftheparotidgland.MethodsTheclinicopathologicaldataof17casesofMCoftheparotidglandtreatedinourhospitalfrom1999to2013wereanalyzedretrospectively.Ofallthe17patients,9casesreceivedradicalsurgeryonly,5casesreceive
5、dpostoperativeradiotherapy,2casesreceivedpreoperativeradiotherapy,andonecasereceivedchemotherapy.ThesurvivalratewascalculatedbyKaplan-Meieranalysis.ResultsAmongthe17patients,11patientshadpost-operativerecurrence(11/17,64.7%),Ofthese11cases,5cases(45.5%)hadrecurrencewithinoneyearafterthef
6、irstoperation.Duringthefollow-upfor12-180months(median50months),sixcasesdied(twopatientsdiedofdistantmetastasesand4casesdiedoflocalrecurrence).Theoverall1-year,2-yearand5-yearsurvivalrateswere94.1%,74.2%and64.9%,andtheoverall1-year,2-yearand5-yearrecurrence-freesurvivalrateswere70.6%,48.
7、1%and40.1%,respectively.ConclusionsRadicalsurgeryisthemaintreatmentmodalityformyoepithelialcarcinomaoftheparotidgland.Forthepatientswithextensivelesionsorafterpalliativesurgery,adjuvantradiotherapyorchemotherapymightbehelpful.However,itstherapeuticefficacyremainstobeprove
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