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1、β-catenin和cyclinD1在子宫内膜癌中表达及临床意义【摘要】目的探讨β-catenin和cyclinD1在子宫内膜癌中的表达及临床意义。方法应用免疫组化SP法检测87例子宫内膜癌和30例正常子宫内膜中β-catenin和cyclinD1的表达。结果β-catenin和cyclinD1在子宫内膜癌中的阳性表达率分别为37.9%(33/87)和43.7%(38/87)，明显高于正常子宫内膜组(P<0.01)。子宫内膜癌中，β-catenin的表达与病理分级、FIGO分期、肌层浸润和淋巴结转移密切相关(P<0.05)，cyclinD
2、1的表达与FIGO分期和淋巴结转移密切相关(P<0.05)。β-catenin和cyclinD1在子宫内膜癌中的表达呈正相关(r=0.458,P<0.01)。结论β-catenin和cyclinD1可能在子宫内膜癌发生发展中起重要作用，可作为评估预后的指标。【关键词】子宫内膜癌β-catenincyclinD1免疫组织化学Expressionofβ-cateninandcyclinD1inendometrialcarcinomapatientsanditsclinicalsignificance.WUShi-min,GUOJun
3、-li,ZHOUSheng,etal.(InstituteofPathology,TongjiHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430030,Hubei，P.R.China;AffiliatedHospitalofHainanMedicalCollege,Haikou570102,Hainan,P.R.China)Abstract：ObjectiveToinvestigatetheexpressionofβ-ca
4、teninandcyclinD1inendometrialcarcinomapatientsanditsclinicalsignificance.MethodsSPimmunohistochemicalmethodwasusedtodetecttheexpressionofβ-cateninandcyclinD1in87casesofendometrialcarcinomaand30casesofnormalendometrium.ResultsThepositiveratesofβ-cateninandcyclinD
5、1inendometrialcarcinomawere37.9%(33/87)and43.7%(38/87)respectively,whichweresignificantlyhigherthanthoseinnormalendometrium(P<0.01).Inendometrialcarcinoma,theexpressionofβ-cateninwassignificantlycorrelatedwiththepathologicalgrade,FIGOstage,myometrialinvasionandthelym
6、phnodemetastasis(P<0.05),whilethatofcyclinD1wassignificantlycorrelatedwithFIGOstageandthelymphnodemetastasis(P<0.05).Therewasapositivecorrelationbetweenβ-cateninandcyclinD1inendometrialcarcinoma(r=0.458,P<0.01).Conclusionβ-cateninandcyclinD1mayplayimportantroles
7、inthedevelopmentandprogressionofendometrialcarcinomaanditcanbeusedasprognosticindicators.Keywords：Endometrialcarcinoma;β-catenin;CyclinD1;Immunohistochemistry子宫内膜癌是妇科最重要的恶性肿瘤之一，近年来发病率有逐渐上升的趋势。β-catenin是一种多功能胞内蛋白，具有细胞间粘附连接及信号转导的双重功能，并参与Wnt信号转导通路激活cyclinD1等癌基因，与肿瘤
8、的发生、发展关系密切［1］。本研究采用免疫组化SP法，检测子宫内膜癌组织中β-catenin及cyclinD1的表达及其与子宫内膜癌病理分级、FIGO分期、肌层浸润和淋巴结转移的关系
