mir-34bvamp2通路在铅暴露影响突触囊泡形成中的作用及机制研究

《mir-34bvamp2通路在铅暴露影响突触囊泡形成中的作用及机制研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、分类号R135.1+1UDC613.6TheFourthMilitaryMedicalUniversity密级公开miR-34b/VAMP2通路在铅暴露影响突触囊泡形成中的作用及机制研究康蓓佩培养类别全日制学位类型学术学位一级学科(专业类)公共卫生与预防医学二级学科(专业)劳动卫生与环境卫生学研究方向环境神经毒理指导教师陈景元教授培养单位军事预防医学系二O一五年四月第四军医大学硕士学位论文目录缩略语表·····················································

2、··········································1中文摘要·······························································································3英文摘要·······························································································7前言··········

3、····················································································11文献回顾······························································································12正文···································································

4、···························26第一部分发育期铅暴露大鼠模型的建立及其对miR-34b表达的影响·············261材料····························································································262方法···············································································

5、·············283结果····························································································324讨论····························································································35第二部分miR-34b下游靶分子的筛选及验证························

6、····················371材料····························································································372方法····························································································403结果····································

7、························································454讨论····························································································49第三部分发育期铅暴露通过miR-34b/VAMP2通路影响突触囊泡形成···········501材料·················································

8、···········································502方法····························································································513结果······································································