生命早期砷、氟暴露对大鼠空间学习记忆及NMDA受体亚基表达的影响

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1、分类号：R114学校代码：10114密级：____学号：051520646生命早期砷、氟暴露对大鼠空间学习记忆及NMDA受体亚基表达的影响EffectsofarsenicandfluorideexposureonspatiallearningandmemoryandexpressionofNMDAreceptorsubunitintheearlydaysofratlife研究生：马文彦指导教师：仇玉兰副教授专业名称：公共卫生研究方向：神经毒理学学位类型：专业学位所在学院：公共卫生学院中国山西二〇一八年六月一日目录摘要............

2、............................................................................................................................IAbstract..............................................................................................................................III前言.........

3、..........................................................................................................................11材料与方法.....................................................................................................................41.1主要仪器与试剂................

4、.....................................................................................41.2实验方法.................................................................................................................62结果...............................................................

5、..............................................................42.1砷、氟染毒仔鼠Morris水迷宫结果..................................................................142.2砷、氟染毒仔鼠海马CA1区HE染色结果......................................................172.3砷、氟染毒对仔鼠海马CA1区LTP的影响....................

6、.................................192.4砷、氟染毒对仔鼠海马组织NMDA受体亚基NR1、NR2A、NR2BmRNA表达水平的影响..............................................................................................................202.5砷、氟染毒对仔鼠海马组织中NMDA受体亚基NR1、NR2A、NR2B蛋白表达的影响...................................

7、...................................................................................233讨论...........................................................................................................................254结论.........................................................

8、..................................................................28参考文献.................