运用五积方治疗非酒精性脂肪性肝炎的临床研究_袁国荣

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1、第29卷第5期中华中医药学刊Vol．28No．52011年5月CHINESEARCHIVESOFTRADITIONALCHINESEMEDICINEMay2011临运用五积方治疗非酒精性脂肪性肝炎的临床研究床研1，233袁国荣，沈凌波，指导:潘智敏(1．浙江省人民医院肿瘤科，浙江杭州310014;2．上海中医药大学，上海200032;3．浙江省中医院，浙江杭州310006)究传摘要:目的:观察五积方治疗非酒精性脂肪性肝炎的临床疗效。方法:59例非酒精性脂肪性肝炎，随机分真为治疗组和对照组，治疗31例，采用潘智敏教授五积方治疗;对照组28例，采用中成药荷丹片进行治疗;疗程均为3

2、个月。结果:五积方能改善非酒精性脂肪性肝炎患者的肝功能，降酶效果优于对照组，具有统计学意义(P＜0．05);治疗组及对照组均可降低血脂TG、CHOL，两组治疗前后有统计学意义(P＜0．01)，但两组降脂效果相当(P＞0．05);治疗组改善患者症状方面优于对照组(P＜0．05);治疗组治疗后影像学显示肝细胞脂肪浸润明显好于治疗前，有统计学意义(P＜0．05)，治疗组改善肝细胞脂肪浸润方面优于对照组，有统计学意义(P＜0．05)。结论;五积方可改善非酒精性脂肪性肝炎患者的肝功能，降低血脂，改善症状及减轻肝细胞脂肪浸润。关键词:非酒精性脂肪性肝炎;五积方;疗效中图分类号:R575．

3、5文献标识码:B文章编号:1673－7717(2011)05－1176－03ClinicalStudyonInstantPowderofWujifangTreatingNon－AlcoholicSteatoHepatitis1，233YUANGuo-rong，SHENLing-bo，PANZhi-min(1．DeparmentofNeoplasm，ZhejiangProvincalPeopleHospital，Hangzhou310014，Zhejiang，China;2．ShanghaiUniversityofTraditionalChineseMedicine，Shang

4、hai200032，China;3．ZhejiangHospitalofTCM，Hangzhou310006，Zhejiang，China)Abstract:Objective:ObservingtheclinicaleffectofInstantPowderofWujifangintreatingNon－AlcoholicSteatoHepatitis(NASH)．Method:59caseswithNASHwererandomlydividedintotheexperimentalgroupandcontrolgroup．Thirty－onepatientsintheex

5、perimentalgroupreceivedInstantPowderofWujifangbyPanZhiminfor3months，twenty－eightpatientsinthecontrolgroupreceivedChineseformulatedmedicineHedanTabletsfor3months．Results:InstantPowderofWujifangcanimprovehepaticfunctionofpatientswithNASH．Forreducingliverenzyme，theclinicaleffectofthetrearmentg

6、roupreceivedInstantPowderofWujifangissuperiortothecontrolgroup，andthedifferenceswerestatisti-callysignificant(P＜0．05);BothexperimentalgroupandcontrolgroupcanreduceTG，CHOL，andcomparisonbeforeandaftereverygrouptreatment，thedifferenceswerestatisticallysignificant(P＜0．01，)．TheeffectofreducingTG

7、，CHOLofexperimentalgroupwasnostatisticsdifferencewithcontrolgroup(P＞0．05)．theexperimentalgroupwassupe-riorthancontrolgroupforimprovingclinicalsymptom(P＜0．05)．theexperimentalgroupshoweditsimagesoffattyin-filtrationoflivercellswassignificantlylowerthanbefo