依托氧气低温等离子体方法制备可用于疝修复的β-环糊精改性pp抗菌补片材料

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1、学校代码10255学号414008DONGHUAUNIVERSITYDoctoralDissertationDevelopmentofantimicrobialpolypropylenemeshmaterialsforherniarepair:bysurfacemodificationwithcoldoxygenplasmaandβ-cyclodextrin依托氧气低温等离子体方法制备可用于疝修复的β-环糊精改性PP抗菌补片材料学科专业：TextileEngineering(纺织工程)a作者姓名：NoorAhmed(阿汗姆)a指导教师：ProfessorWangLu(王

2、璐教授)a答辩日期：2018年05月30日Abstract_____________________________________________________________________________________Developmentofantimicrobialpolypropylenemeshmaterialsforherniarepair:bysurfacemodificationwithcoldoxygenplasmaandβ-cyclodextrinAbstractHerniaisa―ruptureofanorgan‖duetotheweakn

3、essordefectofabdominalsurroundingwalls.Themainreasonofthisdefectisahigherintra-abdominalpressurethatresultsinherniationattheweakestareaoftheabdominalwall.Syntheticmesheshavebeenusedwiththeobjectiveofdeliveringlong-termreinforcementtothedamagedtissuesoftheabdominalhernia.Mostwidelyusedsyn

4、theticmeshesarepolyester(PET),polytetrafluoroethylene(ePTFE)andpolypropylene(PP).However,amongsyntheticlightweightPPmesheshasbeenusedascurrent―goldstandard‖materialforherniarepair.Nevertheless,themaindrawbackoftheseimplantsisthatallsyntheticdevicesfavorinfectionduetotheuneventopographyof

5、knittedmeshes.Thus,meshinfectionisamajorproblemofcurrentPPknittedmeshesandneedtobecuredinearlystagesofmeshimplantationotherwise;secondaryoperationisimposedtoremoveinfectedmesh.Thecurrentmethodformeshinfectionpreventionafterherniarepairisantibioticprophylaxis.However,PPmeshisahydrophobicm

6、aterialwhichdonotabsorbdrug.Thus,meshinfectionremainsmajorcomplicationofherniarepair.Therefore,useofantimicrobialmeshmaterialwithslowdrugreleasecouldbebetteroptiontopreventinfectionaftermeshimplantation.Therefore,thisstudywasfocusingonpreparationofantimicrobialPPmeshesbyincorporatinganti

7、microbialsthatcanbeslowlyreleasedduringearlystageofmeshimplantation.PPmeshsurfacewasmodifiedwithβ-cyclodextrin(CD)andloadedwithantimicrobialwhichcoulddeliverslowreleaseofdrugforthemeshinfectionprevention.This,studyhastakentwonecessarysequentialapproachestoprepareantimicro