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1、33JNMUJournalofNanjingMedicalUniversity200923(1):33-39www.elsevier.com/locate/jnmuResearchpaperRelationshipsbetweendailytotalfluorideintakeanddentalfluorosisanddentalcariesQuanyongXianga,*,MinghaoZhoua,MingWua,XinyaZhoub,LiLinb,JiuningHuangb,YouxingLiangcaJi
2、angsuProvinceCenterforDiseaseControlandPrevention,Nanjing210009,ChinabSuqianCenterforDiseaseControlandPrevention,Suqian223800,ChinacDepartmentofOccupationalHealth,SchoolofPublicHealth,FudanUniversity,Shanghai200032,ChinaReceived2November2008AbstractObjective
3、:Toexploretherelationshipsbetweenthedailytotalintakeoffluoride,dentalfluorosisanddentalcaries.Methods:Anepidemiologicalmethodwasusedtoinvestigatethedailytotalintakeoffluoride,dentalfluorosis,anddentalcariesamong236and290childrenaged8-13yearsinasevereendemica
4、reaandinanon-fluorosiscontrolarea,respectively.Thechildrenweredividedintoeightsubgroupsaccordingtoeachchildsestimateddailytotalintakeoffluoride.Theprevalenceofdentalfluorosisanddentalcariesineachgroupwascalculated.Results:Asexpected,elevatedlevelsoffluoridei
5、ntakeweresignificantlyassociatedwithahigherprevalenceofdentalfluorosisandanincreasingamountofmoreseveredefectdentalfluorosis.WhenthedailytotalFintakewas2.78mg/child/day,theprevalenceofdentalfluorosiswasnearly100%,withtheprevalenceofdefectdentalfluorosisincre
6、asingwithincreasingfluorideintake.Therewasalsoasignificantnegative(inverse)dose-responserelationshipbetweenthedailytotalintakeoffluorideandtheoverallpreva-lenceofdentalcaries,theprevalenceofwhichdecreasedwhenthedailytotalintakeoffluorideincreasedupto3.32mg/c
7、hild/day.However,athigherlevelsofdailytotalintakeoffluoridetheprevalenceofdentalcariesincreased,givingrisetoaU-shapeddose-responserelationshipcurve.Conclusion:Itisimportanttomonitortotalfluorideexposureandprotectchildrenfromexcessivefluorideintake,especially
8、duringtheyearsoftoothdevelopment.Keywords:Fluoride;Dailytotalfluorideintake;Dentalfluorosis;DentalcariesINTRODUCTIONDuringDeansstudies,theprimarysourceofFintakewasconsideredtobedrinkingwater[2].
