左旋四氢巴马汀对戊四氮致痫大鼠的影响

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1、左旋四氢巴马汀对戊四氮致痫大鼠的影响硕士研究生学位论文TheEffectsofL—tretrahydropalmatineonTheEpilepiticRatsInducedBypentylenetetrazolAbstract【Objective]：InordertoevaluatetheprotectiveeffectsofL—n口tothebrainofStatusEpileplicsofPTZepilepsyratmodels,weobervedtheaction，EEG,andultrastrctureofacuteandchronicPTZepilepsyratmode

2、lswhichwereinterferewithL-THPandinvestigatedtheopportunityofL-THPcouldbeusedtotreatepilepsia．IMethods]：1．Acuteepilepsymodel：84healthySDratswererandomlydividedinto6groups，includingthenormalgroup，modelgroup，DiazepamgroupandthethreeRotundinegroupsatlow,middleandhighdoserespectively．2．Pent3rlenete

3、trazole(PTZ)kindlingmodel：42healthySDratswererandomlydividedinto3groups，includingthenormalgroup，modelgroupandthemiddledosegroupofRotundinerespectively．Thechangeofepilepsybehavior,electroencephalogram(EEG)andultrastructurewereobservedaftertheinterventionofthedrugs．【Results]：1．Inacuteepilepsymod

4、el，thetwoRotundinegroupsatlowandmiddledosecouldremarkablyextendthelatencyperiodofSeizures，decreaseattackratetonicconvulsion，cutdowntheamplitudeofelectroencephalographicwaveswhencomparedwiththemodelgroup，moreover'theresultsmentionedabovewererelevanttothedosage．Contrarily,thehi幽doseRotundinegrou

5、pcouldaggravatetheSeizuresymptoms，decurtatethelatencyperiodofSeizures，increasetheamplitudeofelectroencephalographicwaves．normalgroupandDiazepamgroupalldon’tinduceepilepsy．appearanceof4左旋四氢巴马汀对戊四氮致痫大鼠的影响硕士研究生学位论文ultramicrostructure．themitochondriawereinintegrityandtheneuronscellularstructureswe

6、reingearinthenormalgroup．Themitochondriawereinillegibilityandcfistaewerebroken，withthedisruptionoftheinternalandexternalmembraneofthemitochondria，thenecrosisorapoptosisneuronscellscouldbefoundinthemodelgroup．InthetwoRotundinegroupsatlowandmiddledose，themitochondfiawerebasicallyinintact，buttheg

7、apswereswelled(esp．thecristae)，evensomecristaewerelost；theneuronscellswerechangedlittle．Themitochondriawereincloudyconstruction，cfistaewerebroken，withthedisruptionoftheintemalandexternalmembraneofthemitochondriaandthenecrosisorapoptosis