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ID:33899990
大小:3.29 MB
页数:44页
时间:2019-03-01
《hbv复制水平及基因型、亚型对hbv相关性肝病发病的影响》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、第三军医大学硕士学位论文RoleofHBVDNAleVelandgenotype/subtypeonpathogenesisofHBV-associatedliVerdiseasesBackgroundandobjectiVeAbstractHepatitisBVirus(HBV)isamainfactorwhichcausesacuteorchronichepatitis,cirrhosis,liVerfajlureandhepatocellularcarCinoma.InChina,thereareabout23milli
2、onchronichepatitisBpatientsand130millioncarriers,aIldapproximately50percentofhepatocellularcarcinomaoccurredinChina.HepatitisBVims(HBV)hasbeenclaSsifiedintoeightgenotypeslIA-H)basedonanintergroupdiVergenceof8%ormoreinthecompletenucleotidesequence.InChina,thereaurefo
3、urgenotypes⋯一A,B,CaJldD,andthepercentageofeachofthemis1.2%,39.3%,50.2%and8.1%respectiVely.GenotypeshaVedifferentgeo铲aphicdistribution:genotypeCisprimaryfoundintheno砒ofChina(about81.6%)andinthesouthofChina,genotypeBisthemainone.TheinVest培ationofHBVsubgenotypehasbeenc
4、arriedoutinrecentyears.HuyanalyzedtheHBVsequencesofgenotypeCpatientsfromSoutheastAsiaandtheFarEastanddiVidedthemintotwosubtypes:C1(Cs)andC2(Ce).ClsubtypeisfromSoutheastAsia,likeVietnamandThailand。C2subtypeisfromtheFarEast,likeChina,JapanaIldRepublicofKorea.GenotypeB
5、canalsobediVidedintotwosubgenotypes:Baand功.TheresearchesinandoutourcountryindicatedthatHBVgenotypepossiblycloselycorrelatewithdiseaseprOceeding,clinicalmanifestation,prognosisandantiViraltherapyresponse.ResearchersnowgenerallyconsiderthattheinflammatorynecrosisaIldf
6、ibrosisconditionsaremoreseriousinpatientswithgenotypeCthanthosewithgenotypeB,andHBeAgpositiVerateishigberinpatientswithgenotypeC;genotypeCisrelatedwithcirrhosisandhepatocellularcarcinoma;genotypeBhashigheraccumulationsurViValratethangenotypeC.Butsomestudiesinourcoun
7、tryindicatedthatthedifferencesofhepatiticfunctionallesion,inflamatorynecrosisandfibrosishaVenostatisticallysignificantbetweenthetwogenotypes.2第三军医大学硕士学位论文BasedOnthis,wechosepatientswhoinfectedwithHBVaIldwereindifferentphasesinSouthwestasobjectsforinVestigation,HBVDN
8、AleVel,HBeAg,anti—HBe,HBVgenotypesandsubtypesweremonit01.ed.Tobefirst,westudiedthedistributionoftheageandHBVDNAlevelofpatientswhosuf托redfr
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