资源描述：
《25.Effect of Cyclic Loading on in Vitro Degradation of Poly L-lactide-co-glycolide Scaffolds.pdf》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、ArticleBiomaterialsApril2011Vol.56No.10:982–986doi:10.1007/s11434-010-4132-1SPECIALTOPICS:EffectofdegradationofPLGAandPLGA/β-TCPscaffoldsonthegrowthofosteoblasts11122YANGYanFang,TANGGongWen,ZHAOYunHui,ZHANGYang,LIXiuLan&1*YUANXiaoYan1SchoolofMaterialsScienceandEngineering,TianjinKeyLabor
2、atoryofCompositeandFunctionalMaterials,TianjinUniversity,Tianjin300072,China;2InstituteofOrthopedics,TianjinHospital,Tianjin300211,ChinaReceivedApril8,2010;acceptedAugust4,2010;publishedonlineNovember1,2010Osteoblastswereculturedonporousscaffoldsofpoly(L-lactide-co-glycolide)(PLGA)andPLG
3、A/β-tricalciumphosphate(β-TCP)toevaluatetheircytocompatibility.Theproliferationofthecellsonbothscaffoldswasexaminedbeforeandafterinvitrodegra-dationfor4,8and12weeksunderstatic(shakingwaterbath)anddynamic(cyclicloading)conditions.Resultsindicatethatpo-rousPLGAandPLGA/β-TCPscaffoldshavegoo
4、dbiocompatibilityandcanbeusedaseffectivetemplatesforguidingthegrowthofosteoblasts.Thedegradationofthescaffoldsaffectstheproliferationofosteoblastsandthecellviabilitydecreasedwiththedegradationtime.PLGA,β-TCP,scaffold,degradation,osteoblastCitation:YangYF,TangGW,ZhaoYH,etal.Effectofdegrad
5、ationofPLGAandPLGA/β-TCPscaffoldsonthegrowthofosteoblasts.ChineseSciBull,2011,56:982−986,doi:10.1007/s11434-010-4132-1Becauseofthelimitationsofautograftsandallografts,manyproliferationstudiesofhumanfetalosteoblastsseededoneffortshavebeenmadeoverthepasttwodecadestopreparepoly(ε-caprolacto
6、ne)/β-TCPscaffoldsshowedthegreatidealbonerepairbiomaterialsfromtheviewpointoftissuepotentialofthesescaffoldsthatcanmimicthecomplexele-engineering[1].Oneofthemostimportantobjectivesofganceofnativetissue[3].Furthermore,Kuoetal.[4]re-bonetissueengineeringistodesignanddevelopadequateportedth
7、atbonemarrowstromalcellsgrewwellonbiodegradablescaffoldsforcellstoadhere,proliferateandPLGA/chitosanscaffolds,indicatingthatbiodegradabledifferentiate,inadditiontoguidingtheformationofboneporousscaffoldscansupplyathree-dimensionaltemplatetissue[2].Polylactide,polyglycolid
