资源描述：
《子宫内膜异位症模型中大鼠输卵管特络细胞超微结构损伤的分析》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、UltrastructuralobservationsoftelocytesdamageinratmodelofoviductendometriosisAbstractPart1ConstructionofanimalmodelofoviductendometriosisinratsObjective:Animalmodelofoviductendometriosisinratswasconstructed,andcanbeusedforresearchontubalfactorinfertil
2、ityinendometriosis;Methods:40femaleSprague-Dawleyrats(250～300g)weredevidedintotwogroupsaveragely.Theautotransplantionmodelofendometriosisatthemesenteryofoviductofratswasusedtoconstructthemodel,withthecontrolmodelreceivingonlyblanksutureincorrespondin
3、gsite.Twomonthslater,theratswerekilled,endometrioticvesicles,oviductinflammation,andcharacteristicendometrioticchangeswerepresentedinlesionsofoviductinlightmicroscope.ThechangesofmicroenvironmentinoviductsuchasCOX-2,iNOS,LPOandEstrogenwasdetectedbyim
4、munofluorescencestainingcombinedwithconfocallaserscanningmicroscopy;Results:1.Twomonthslater,vesiclespresentedintransplantationsiteofexperimentalrats,withthincysticwallandtransparentyellowcystfluid,andmesenteryofoviductwereinvadedbyvesicles.2.Themuco
5、salfoldsinlesionsofoviductweredisappeared,andendometrialglandswerefoundinmuscularlayer,withvariabledegreesoffibrosis,85%samplesweresuccessfullyconstructedintodesiredmodel.3.Inexperimentalgroup,thelevelsofCOX-2,iNOS,LPOandEstrogenofoviducttissueweresi
6、gnificantlyhigherthanthatofnormalcontrolgroup,withPvaluelessthan0.05;Conclusions:Theratmodelofendometriosisatthemesenteryofoviductbythismethod,conformstopelvicmicroenvironmentchangeinpatientswithendometriosis,andcanbeusedasanidealanimalmodeltoresearc
7、honEMs-TFI.Keywords：Oviductendometriosis;Animalmodels;Microenvironment;TubalfactorinfertilityPart2UltrastructuralobservationsoftelocytesdamageinratmodelofoviductendometriosisObjective:Endometriosis(EMs)frequentlycomplicatedwithinfertilityinclinic.The
8、aimofthisstudywastoobserveultrastructuralalterationsoftelocytes,discusspotentialconsequencesonstructureandreproductivefunctionofoviduct.Methods:AutotransplantationofSpragueDawleyratmodelofEMsaffectedoviducttissuewasusedforultrastructureobservationbyt
