cox-2在胃溃疡、胃癌的表达及其与hp感染关系的研究

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1、中图分类号：R573硕士学位论文COX-2在胃溃疡、胃癌的表达及其与HP感染关系的研究院（系）、所临床医学院研究生姓名霞晓燕学科、专业内科学导师姓名文黎明教授二Ο一二年四月1目录1COX-2在胃溃疡、胃癌的表达及其与HP感染关系的研究„„„„„„„„„„„„„„„„„„„„„„„„11.1中文摘要„„„„„„„„„„„„„„„„„„„„„11.2英文摘要„„„„„„„„„„„„„„„„„„„„„31.3前言„„„„„„„„„„„„„„„„„„„„„„„51.4材料与方法„„„„„„„„„„„„„„„„„„„„71.5结果„„

2、„„„„„„„„„„„„„„„„„„„„„141.6讨论„„„„„„„„„„„„„„„„„„„„„„„231.7结论„„„„„„„„„„„„„„„„„„„„„„„271.8参考文献„„„„„„„„„„„„„„„„„„„„„281.9英汉缩略词对照表„„„„„„„„„„„„„„„„„302致谢„„„„„„„„„„„„„„„„„„„„„„„313COX-2在胃溃疡、胃癌的表达及其与HP感染关系的研究（综述）„„„„„„„„„„„„„„„„„„„„„„„„„322COX-2在胃溃疡、胃癌的表达及其与HP感染关系的研究摘要目的：探讨

3、COX-2在HP感染与非感染性胃溃疡及胃癌的表达。方法：用免疫组化方法检测196例经胃镜和组织病理学检查患有胃溃疡（病理分型：肠上皮化生、异型增生）、胃癌及大致正常胃粘膜者的胃粘膜COX-2蛋白的表达，比较各病理分类之间及HP感染与非感染之间COX-2蛋白表达的差异。结果：本研究发现肠上皮化生、异型增生、胃癌组的炎症细胞、腺上皮细胞、癌细胞及极少量正常黏膜上皮细胞中有COX-2表达。从肠上皮化生—异型增生—胃癌COX-2的阳性表达有逐渐增强的趋势(P<0．05)。胃癌组COX-2的阳性表达高于胃溃疡组(P<0．05)，Hp阳

4、性胃癌组COX-2的阳性表达高于Hp阳性胃溃疡组(P<0．05)，Hp阴性胃癌组COX-2的阳性表达也高于Hp阴性胃溃疡组(P<0．05)。各Hp阳性实验组COX-2的阳性表达显著高于Hp阴性(P<0．05)，各Hp阳性实验组COX-2的阳性表达有差别(P<0．05)，Hp阳性胃癌组COX-2的阳性表达高于Hp阳性胃溃疡组(P<0．05)，而且Hp阳性胃溃疡组COX-2的阳性表达高于Hp阴性(P<0．05)。结论：①COX-2通常在正常组织中不表达，只有在受到各种物质如炎症介质、细胞因子、促癌剂等刺激下在炎症部位表达。②从肠

5、上皮化生—异型增生—胃癌COX-2的阳性表达有逐渐增强的趋势,COX-2的过度表达参与了胃癌前期病变和胃癌的发生发展过程。③Hp感染可诱导COX-2的过度表达。④COX-2在Hp感染的胃黏膜中过度表达，有加剧炎症反应和加快从浅表性胃炎—肠3化、异型增生—胃癌这一过程的作用，Hp感染可能通过诱导COX-2过度表达参与胃癌发生发展的早期过程。关键词：COX-2;胃溃疡;胃癌；Hp4COX-2ingastriculcer、gastriccancerandHPinfectionoftheexpressionandresearchof

6、therelationshipAbstract:Objective:ExploreCOX-2intheHPinfectionandnoninfectiousgastriculcerandgastriccancerexpression.Methods:Immunohistochemicalmethoddetectionwith196casesbygastroscopeandhistopathologicalexaminationwithgastriculcer(pathologyclassification:intestina

7、lmetaplasia,hyperplasia),stomachandnormalgastricmucousmembraneoftheroughlythegastricmucosaCOX-2proteinexpression,ComparisonbetweenthepathologyclassificationandHPinfectionwiththeinfectionsCOX-2betweenproteinexpressionofthedifferences.Results:Thisstudyfoundthatintest

8、inalmetaplasia,hyperplasia,stomachgroupofinflammatorycells,glandularepitheliumcells,cancercellsandnormalmucosainverysmallamountsofepithelialcells