丹红注射液对大鼠移植肾缺血再灌注损伤保护作用的研究

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1、重庆医科大学硕士研究生学位论文expressionofBaxandBcl一2inkidneywerequantitativelydetectedbyimmunohistochemistry．CellapoptoticindexwasmeasuredbyTUNELmethod．Results：1．Thereweresignificantpathologicalchangesinkindeytissueappearanceinkidneytransplantgroup(thekidneytubularepithelialcellsarranged

2、disorderly，differentdegreesofnecrosis，pyknosisandinflammatorycellinfiltrations)comparedwithshamgroup．TherearenotobviouschangesinDanhongtreatmentgroupComparedwithkidneytransplantgroup．ComparedwiththoseinkidneytransplantgroupandDanhongtreatmentgroup，thekindeytubulesepithelial

3、cellsswelledmildlyandtheinflammatorycellinfiltrationwasobviouslyrelievedinDanhongpretreatmentgroup．2．ComparedwiththoseintheShamgroup，theothergroupsBUNandCRincreasetohigherlevel(P0．05

4、)．ComparedwiththoseinkidneytransplantgroupandDanhongtreatmentgroup，BUN(45．16士6．50mmol／Lw69．96士6．22mmol／L，P<0．01；45．16士6．50mmol／Lvs67．12士5。86mmol／L，P

5、ntly．3．ComparedwiththoseintheShamgroup，thecellapoptoticindex重庆医科大学硕士研究生学位论文(39．07％士2．57％vs5．17％+1．18％，P

6、antgroupandDanhongtreatmentgroup，theapoptoticindex(21．18％士1．58％vs39．07％士2．57％，尸

7、mentgroup．Conclusion：1．Kidneyischemia—reperfusioninjurycancausemajorinjuryofnephridialtissue，inhancedinflammationcellinfiltrationinthekindeytissue，inducedtheaggravationofkindeyfunction．2．Apoptosisparticipateinischemicalreperfusioninjury,andBcl一2、Baxgenealsoarticipateinische

8、micalreperfusioninjury．TheydecideapoptoticindexbyregulatingBcl-2／Baxexpression．3．U