早发性帕金森病与晚发性帕金森病全脑基于体素的mri形态分析

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1、浙江大学硕士学位论文早发性帕金森病与晚发性帕金森病全脑基于体素的MRI形态分析姓名：任冬冬申请学位级别：硕士专业：神经病学指导教师：罗巍201204浙江大学硕士学位论文英文摘要WholebrainVoxel-based^侧morphometricstudyofearly-onsetParIdnson’sdiseaseandlate．onsetParkinson’sdiseaseDepartmentofneurologySchooIofMedicine，ZhejiangUniVersityPostgraduateRenDongdongSupen，is

2、orLuoWeiAbstractobjecti、，e：Early—onSetParkinson’sdiseaSe(EOPD)isdistinct自omtllecl孙siclate-onSetPd曲S0n’sdiseaSe(LOPD)becauseofitsslo、verdis铋Sepro蓼essionandlesscogIlitiVeimp洳ent．The咖lofthestudyistocomparetlle谢hole-b池challgesi11EOPD谢也thatinLOPD、加也thes锄ediseased啪tio玛t11rou曲、，0xel-

3、b觞edmo印home吧ⅣBM)study，w托ch、^，ill妇proVe也eu11ders啪dingofpatllo．physiologymechanism，clinicalch甜翟cteristics如ddise雒emollito血gi11EOPD．Method：nliny·mnepatientS．sixteenEOPD(<50years)锄dtwenty-threeLOPD(>50years)．matchedfordiseaLsedur钒ionweresc锄ed诵也VBMina3．OTe。slaMⅡUsc枷er锄d髂sessedinclim

4、cwitllstalldardPDscales．Thedataw2Lscollected卸danalyzedbySPM8togenerategra、，matterdensitymap．IResult：nereafenosigllific锄tdi仃erencesinUIlitedParkjnsonDise鼬eRatingScale·IIlⅣPDRS·III)score．Hoelln-、蚀ngrading饵·YFading)．Mini-mentalstateV浙江大学硕士学位论文英文摘要ex雅曲ation(MMSE)score髓d011Setsidec

5、omp痂gEOPDtoLOPD．HoweVer．VEIMreVealsincreaSedgraym撒盯densi够i11le矗sup丽orandmedim丘Io删g)仉琏1enparallippoc砒npus鼢仉lSaIldcingulategyTllSinEOPD．Conclusion：mgraymatterdens时di舵rellcesi11le金sup硎ora11dmedia】硒ntaJgynlSmayrenliIldacompenSatorymech柚isminPD．And也eiIlcreaSedgraym施eri11leRp缸撕ppoca

6、Inpusgyrus觚dcillgulategyruSi11EOPDmayberelatedt0抵lessmen词证lpaimlem．BothoftlleresultSproVideaprobablemo印hologic翻proofto也ecl“c龇m锄ifestationofEOPD．Keywords：E州y—onsetP划血son’sdiseaSe(EOPD)；Hoehn-Yahngrading(H—Y笋ading)；Late—onSetParld=nSon：sdise2Lse(LOPD)；UIlitedPa订dnSonDiseaSeRatil

7、lgSc乱e-III几用DRS—III)；Vbxel．baSedmo巾home廿yⅣBM)VI浙江大学硕士学位论文中文摘要早发性帕金森病与晚发性帕金森病全脑基于体素的M砒形态分析浙江大学医学院神经病学’硕士研究生任冬冬导师罗巍副教授副主任医师中文摘要目的：早发性帕金森病(Early-0ns殴Parkinson’sdise龉e，EOPD)与晚发性帕金森病(k此·onSetParl(inson’sdise觞e，LOPD)在临床表现上有诸多差异，主要为EOPD进展相对缓慢，精神症状相对少见．本研究拟在此基础上应用M对基于体素的形态学测量方法(、，0xel

8、．bausedmo印home勺％VBM)，分析相同病程下EOPD与LOPD患者全脑结构是否存在差异，为其发病机制、临床特点