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1、提要目的：观察固本舒脉汤治疗老年难治性心绞痛的临床疗效并探讨其作用机制。方法：临床研究将60例老年难治性心绞痛阳虚脉阻型患者随机分为两组，治疗组30例，给予固本舒脉汤结合西医常规治疗；对照组30例，给予西医常规治疗，疗程60天。结果：1、固本舒脉汤治疗老年难治性心绞痛疾病疗效总有效率83.4%，显效率56.6%；2、心绞痛疗效治疗组总有效率86.7%，显效率60%；3、动态心电图疗效总有效率73.4%，显效率43.3%；4、中医症状改善总有效率90%，显效率46.7%，均明显优于对照组（P＜0.05或P＜0.01）；
2、5、治疗组治疗前后比较，治疗组与对照组，固本舒脉汤结合西医常规治疗可显著降低TG、LDL-C、TC、提高HDL-C，与对照组相比有显著差异（P＜0.05或P＜0.01）。结论：本研究完善了中药在现代危重病治疗的理论内容，肯定了中医药在危重病治疗中的作用，认为固本舒脉汤结合西医常规治疗在改善老年难治性心绞痛的病情方面疗效显著，为进一步深入研究中药治疗难治性疾病奠定了基础。关键词固本舒脉汤；老年难治性心绞痛；阳虚脉阻；临床研究TheClinicalStudyonanginapectorisofelderpatientsw
3、ithRefractoryAnginabyGubenshumaiFormulaSpeciality：InternalMedicineofTraditionalChineseMedicineAuthor：FangLihuaTutor：Prof.BaoPei-rongAbstractObjective:TheclinicalefficacyoftheobservedstrengtheningthefoundationShudecoctiontreatmentofelderlypatientswithrefractorya
4、nginapectorisandtoexploreitsmechanismMethods:Theclinicalstudyof60casesofelderlyrefractoryanginapectorisyangpulseresistancewererandomlydividedintotwogroups,treatmentgroup30cases,thecombinationofconventionalWesternmedicinetreatmentgiventostrengtheningtheeconomySh
5、umaiSoup;controlgroup(n=30),givingWesternconventionaltreatmentcourseof60days.Results:1GubenShumaiSoupdiseaseefficacyofthetreatmentofelderlyrefractoryanginatotalefficiencyof83.4%,markedlyeffectiverate56.6%;anginatreatmentgroupthetotaleffectiveratewas86.7,markedl
6、yeffectiveratewas60%;ECGefficacy,efficiency73.4%,markedlyeffectiverate43.3%;,clinicalsymptomstoimprovethetotalefficiencyof90%,markedlyeffectiveratewas46.7%,significantlybetterthanthecontrolgroup(P<0.05orP<0.01);5,thetreatmentgroupbeforeandafterthetreatmentgroup
7、andcontrolgroup,theGubenShumaisoupcombinedwithroutinewesternmedicinecanbeasignificantreductionofTG,LDL-C,TCandincreaseHDL-C,withthecontrolgroupcomparedtothesignificantdifference(P<0.05orP<0.01).Conclusion:ThisstudyimprovedthetheoryofChinesemedicineinmoderncriti
8、calcaretreatment,affirmedtheroleofChinesemedicineinthetreatmentofcriticallyill,thatGubenShudecoctioncombinedwithroutinewesternmedicineintheconditiontoimproveelderlypatientsw
