化浊行血汤对短暂性脑缺血发作患者的临床干预研究

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1、提要目的：基于治未病理论观察化浊行血汤对短暂性脑缺血发作患者的临床治疗及预防效果。方法：采用随机对照的研究方法，选择符合标准的患者60例，根据随机数字表，按就诊时间顺序依次分为对照组和治疗组各30例。对照组予以西医综合治疗，观察组在西医综合治疗的基础上加用化浊行血汤，疗程为3个月。结果：临床观察发现，观察组总有效率明显优于对照组（P﹤0.05）；化浊行血汤能够降低TIA患者的发作频次，两组比较有显著性差异（P﹤0.05）；观察组患者血同型半胱氨酸、纤维蛋白原、血脂分析、血液流变学、超敏C反应蛋白较对照组有明显改善（P﹤0.05）；两组患者神经元特异性烯醇化酶及发展为脑梗死例数无统计学意义（P

2、﹥0.05）。结论：化浊行血汤能够显著改善TIA患者的临床症状，减少TIA患者的发作频率及改善患者血同型半胱氨酸、纤维蛋白原、血液流变学及超敏C反应蛋白各项理化指标，尤其在降脂方面疗效显著，虽然对终点事件的统计无统计学意义，综合分析考虑与样本量小及临床观察时间短有关，但能够降低TIA患者发展为脑梗死的百分比，对短暂性脑缺血发作患者起到治疗及二级预防的作用，体现了治未病理论中“未病先防，既病防变”的思想。关键词血浊；化浊行血汤；短暂性脑缺血发作；临床研究Huazhuoxingxuetangtotransientischemicattackpatient'sclinicalinterventio

3、nresearchSpeciality:NeurologicalmedicineofTCMAuthor:ZongShoujianTutor:Prof.WangXingchenAbstractObjective:basedontheoryaboutpreventionandinterventionobservehuazhuoxingxuesouptotransientischemicattackpatient'sclinicalcareandthepreventioneffect.Methods:Randomizedcontrolledstudy,60patientsstandard,acco

4、rdingtotherandomnumbertable,theorderofthetreatmenttimeisinturndividedinto30casesofthecontrolgroupandtreatmentgroup.ThecontrolgroupwastreatedwithTCMandWesternmedicinetreatment,observationgrouponthebasisofTCMandWesternmedicinetreatmentwithhuazhuoxingxuesoupcourseoftreatmentforthreemonths.Result:Thecl

5、inicalobservationdiscovery,thejointhuazhuoxingxuesoupandWesternmedicinetreatmentthanasimpleWesternmedicinetreatmentofclinicalefficacyweresignificantdifference(P<0.05),observedagroupofserumhomocysteinefibrinogen,bloodlipidanalysisrheology,highsensitivityC-reactiveproteincomparedwiththecontrolgroupim

6、provedsignificantly(P<0.05);NSEandthedevelopmentoftwogroupsofpatientswithcerebralinfarction,thenumberofcasesnotstatisticallysignificant(P>0.05).Conclusion:huazhuoxingxuesouptobeabletoibeabletoimprovethepatient'sbloodhomocysteinefibrinogen,lipidanalysis,bloodrheologyandhighsensitivityC-reactiveprote

7、inphysicalandchemicalindicators,playatransientischemicattackpatientstreatmentandsecondarypreventionrole.KeyWord:bloodmuddy;xuazhuoxingxuetang;transientischemicattack;Clinicalresearch.目录引言...................