二维斑点追踪成像技术评价糖尿病患者左心室功能早期改变

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2、IUllIIIIIIIIlllUIIIY2338683Assessmentofearlychangeofleftventricularfunctionintype2diabetesmellitususingtwo—dimensionalspeckletrackingimagingAbstractObjectiveToinvestigatetheclinicaivalueoftwo—dimensionalspecHetrackingimaging(STI)inassessmentofearlychangeofleftventricular(LV)systolicfuncti

3、onoftype2diabetesmelIitus(T2DM)．MethodsNinety—fivesubjects(LVejectionfraction≥50％)wereincluded：32T2DM、^，ithdiabetesmellitusonly(groupA)，31T2DM谢tllbothdiabetesandleftventricularhypertrophy(groupB)，and32normalcontrols．Two-dimensionalstrainimageswerecollectedfromapicallong-axis，four-chamber，tw

4、o-chamberviews，andLVshort-axisviewsatlevelsofmitralannulus，papillarymuscleandapex．TheLVsystolicpeaklongitudinal，radial，circumferentialstrainofeachplaneweremeasured，andaveragepeakstrainwereassessed．ResultsPeaklongitudinal，circumferentialstrainandaveragepeakstraininbothT2DMgroups(A，B)weresign

5、ificantlyreducedthanthatofcontrols(P0．05)．Conclusionstwo-dimensionalspeckletrackingimagingcouldbeusedtoidentifytheearlychangeofLVlocalsystolicfun

6、ctioninT2DM．Postgraduatestudent：MAShuxian(Echocardiography)DirectedbyProf．JiangZhirongKeywords：Echocardiography；diabetesmellitus，type2；ventricularfunction，left；speckletrackingimaging引言⋯⋯⋯⋯⋯⋯⋯⋯⋯·第一章资料与方法目录21．1研究对象⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯·21．2仪器⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯

7、一21．3研究方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯21．4统计学处理⋯⋯：¨⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯一3第二章结果⋯⋯⋯⋯⋯⋯⋯·⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯4●2．1糖尿病组和对照组一般临床资料比较⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯42．2常规超声心动图参数比较⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯42．3糖尿病组和对照组左室心肌STI参数比较⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯4第三章讨论⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯·53．1研究糖尿病患者心脏功能的意义⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯

8、⋯⋯⋯⋯⋯⋯⋯⋯⋯53．2糖尿病致心脏损害的病理基础⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯53．3临床常用检测糖尿病患者心脏的超声技术⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯53．4STI技术检测糖尿病患者心脏功能⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯83．5研究的局限与展望⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯·10结论参考文献综述⋯⋯⋯”综述的参考文献攻读学位期间的研究成果附录⋯⋯⋯⋯⋯⋯⋯⋯⋯”致谢⋯⋯⋯1l12⋯⋯14学位论文独创性声明、学位论文知识产权权属声明2l24253l32引言引