海马hcn通道在慢性内脏痛大鼠中枢敏化中作用

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1、万方数据目录目录.......................................................................................................................................................................1中英文缩略词表···················································································2中文摘要···············

2、··············································································3英文摘要·····························································································5前言···································································································8材料与方法··

3、························································································10结果···································································································18讨论···························································································

4、········40结论···································································································46参考文献····························································································47致谢·········································································

5、···························52综述··································································································531万方数据中英文缩略词表ACSFArtificialcerebrospinalfluid人工脑脊液CIColonirritation结肠刺激CRDColorectaldistension结直肠扩张EMGElectromyogram肌电图EOMAExternalobliquemuscleofabdomen腹外斜

6、肌EPSPExcitatorypostsynapticpotential兴奋性突触后电位HCNHyperpolarization-activatedcyclic超极化激活环核苷酸nucleotide-gatedchannels门控阳离子通道HFSHighfrequencystimulation高频刺激IBSIrritableBowelSyndrome肠易激综合征IODIntegrateopticaldensity积分光密度LTPLong-termpotentiation长时程增强效应NFANiflumicacid尼氟酸SDSprague-DawleyratsSD大鼠

7、4-(N-ethyl-N-phenylamino)-4-(N-乙基-N-苯氨基)ZD72881,2-dimethyl-6-(methylamino)-1,2-二甲基-6-pyrimidiniumchloride甲氨基氯化嘧啶2万方数据海马HCN通道在慢性内脏痛大鼠中枢敏化中的作用中文摘要目的观察海马超极化激活环核苷酸门控阳离子通道（HCN通道）对慢性内脏痛大鼠痛觉敏感性的影响并探讨其作用机制，以期深入了解慢性功能性内脏痛的发病机制，从而为慢性内脏痛的药物治疗提供新的作用靶点。方法选用新生SD大鼠，出生后8～14d内，每天固定时间给予一次60mmHg压力的结直肠刺